Full Description
Henry Jay Forman, Jon Fukuto and Martine Torres "Research is to see what everybody else has seen and to think what nobody else has thought. " -- Albert Szent-Gyorgyi Several years ago, one of us put together a book that dealt with various aspects of oxidative stress and introduced the concept of signal transduction by oxidants. Since then, the interest in the mechanisms by which reactive oxygen and nitrogen species (ROS/RNS) can modulate the cell's response has tremendously grown, paralleling the intense efforts towards identifying new signaling pathways in which phosphorylation/dephosphorylation events take center stage. Evidence is now mounting that production of these species by the cells is required for their function from growth to apoptosis and numerous signaling pathways have been identified where the participation of ROS and RNS is apparent (see Chapters 11-14, 16 and 18). Thus, the field is no more limited to the group of free radical aficionados who have pioneered this area of research but has now gone mainstream. While it is satisfactory for those of us who have been working on this topic for a long time, it has the risk of becoming the "fashionable" motto where those molecules, still mysterious to some, become responsible for everything and anything.
Contents
Redox State and Redox Environment in Biology.- Sulfur and Selenium Catalysis as Paradigms for Redox Regulations.- Thiols of Thioredoxin and Glutaredoxin in Redox Signaling.- Reactivity and Diffusivity of Nitrogen Oxides in Mammalian Biology.- Bacterial Peroxiredoxins.- The Nox Enzymes and the Regulated Generation of Reactive Oxygen Species.- NO Synthesis and NOS Regulation.- S-nitrosothiols in Cell Signaling.- Hydrogen Peroxide as Intracellular Messenger: Identification of Protein Tyrosine Phosphatases and Pten as H2O2 Target.- 4-Hydroxynonenal Signaling.- Ceramide Signaling under Oxidative Stress.- Map Kinases in Redox Signaling.- Activation of Prostaglandin Biosynthesis: Peroxynitrite vs Hydroperoxides.- Phylogenetic Conservation of the Nrf2-Keap1 Signaling System.- The NO-cytochrome C Oxidase Signaling Pathway; Mechanisms and Biological Implications.- The Concept of Compartmentalization in Signaling by Reactive Oxygen Species.- Role of Mitochondrial Oxygen and Nitrogen Reactive Species in Signaling.- Redox Regulation of Gene Expression: Transcriptional Induction of Heme Oxygenase-1.- Apoptosis Mechanisms Initiated by Oxidative Stress.- Reactive Oxygen and Nitrogen Species in the Production of Congenital Malformations by Known Teratogenic Agents and Maternal Conditions.
