基本説明
Providing a valuable overview this issue will be of interest not only to those engaged in genetic research but also to clinicians concerned with fetal medicine and with infertility.
Full Description
Aneuploidy is the most commonly occurring type of chromosome abnormality. It occurs usually because of segregation errors that take place during female meiosis. Most aneuploid pregnancies do not survive in utero and in the great majority of cases demise happens during the first few weeks of uterine life. This publication investigates the causes of aneuploidy in humans and its effects at different life stages. This issue is accordingly divided into three main sections: the first, 'Aneuploidy at Different Life Stages', provides an overview of abnormalities in sperm and oocytes. In addition, current literature dealing with inherited aneuploidy arising from germinal mosaicism is reviewed. The second section provides in-depth coverage of aneuploidy during embryogenesis together with articles about somatic changes. Furthermore, an exciting collection of up-to-date articles by highly regarded experts in the field explore the topic of genetic regulation of chromosome segregation. The final section is devoted to 'Environment and Epigenetics', two critical factors in the genesis of aneuploidy. Providing a valuable overview this issue will be of interest not only to those engaged in genetic research but also to clinicians concerned with fetal medicine and with infertility. Furthermore, embryologists who need to be familiar with the latest findings relating to embryonic aneuploidy will doubtless appreciate these reviews.
Contents
Preface: Delhanty, J.D.A.; Pellestor, F.; Aneuploidy at Different Life Stages: Gametic; Aneuploidy in Human Spermatozoa: Templado, C.; Vidal, F.; Estop, A.; Aneuploidy and DNA Fragmentation in Sperm of Carriers of a Constitutional Chromosomal Abnormality: Perrin, A.; Basinko, A.; Douet-Guilbert, N.; Gueganic, N.; Le Bris, M.-J.; Amice, V.; De Braekeleer, M.; Morel, F.; Chromosome Abnormalities in the Human Oocyte: Fragouli, E.; Wells, D.; Delhanty, J.D.A.; Whole-Chromosome Aneuploidy Analysis in Human Oocytes: Focus on Comparative Genomic Hybridization: Obradors, A.; Rius, M.; Daina, G.; Ramos, L.; Benet, J.; Navarro, J.; Predisposition to Aneuploidy in the Oocyte: Vialard, F.; Boitrelle, F.; Molina-Gomes, D.; Selva, J.; Inherited Aneuploidy: Germline Mosaicism: Delhanty, J.D.A.; Aneuploidy at Different Life Stages: Embryonic and Prenatal; Aneuploidy in the Human Cleavage Stage Embryo: Mantzouratou, A.; Delhanty, J.D.A.; Aneuploidy in the Human Blastocyst: Frogouli, E.; Wells, D.; The Human Cleavage Stage Embryo Is a Cradle of Chromosomal Rearrangements: Voet, T.; Vanneste, E.; Vermeesch, J.R.; Mosaic Aneuploidy in Early Fetal Losses: Lebedev, I.; Aneuploidy at Different Life Stages: Somatic; Sporadic Aneuploidy in PHA-Stimulated Lymphocytes of Trisomies 21, 18, and 13: Reish, O.; Regev, M.; Kanesky, A.; Girafi, S.; Mashevich, M.; Mechanisms of Whole Chromosome Gains in Tumors - Many Answers to a Simple Question: Gisselsson, D.; Meiotic Studies of a 38,XY/39,XXY Mosaic Boar: Pinton, A.; Barasc, H.; Raymond Letron, I.; Bordedebat, M.; Mary, N.; Massip, K.; Bonnet, N.; Calgaro, A.; Dudez, A.M.; Feve, K.; Riquet, J.; Yerle, M.; Ducos, A.; Genetic Regulation of Chromosome Segregation; New Insights into the Genetic Regulation of Homologue Disjunction in Mammalian Oocytes: Homer, H.; Sister Chromatid Cohesion Control and Aneuploidy: Barbero, J.L.; The Role of Shugoshin in Meiotic Chromosome Segregation: Clift, D.; Marston, A.L.; Prevention and Correction Mechanisms behind Anaphase Synchrony: Implications for the Genesis of Aneuploidy: Matos, I.; Maiato, H.; Environment and Epigenetics; Environmental Hazard in the Aetiology of Somatic and Germ Cell Aneuploidy: Pacchierotti, F.; Eichenlaub-Ritter, U.; Male Fertility, Chromosome Abnormalities, and Nuclear Organization: Ioannou, D.; Griffin, D.K.; Is There a Paternal Age Effect for Aneuploidy? Fonseka, K.G.L.; Griffin, D.K.
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