Full Description
This publication describes in detail some animal models of outstanding importance for the study of human neurological diseases. An introductory article provides a definition of animal models, looks at the history and ethics of their use, and highlights the reasons why animal models are so useful in scientific research. The following chapters present some of the newer models which play a key role in the study of amyotrophic lateral sclerosis, multiple sclerosis, stroke and peripheral neuropathy. Their specific features are detailed in the method section of each paper, and their application to the study of human neurological diseases is discussed in a comprehensive manner, i.e. limits and challenges posed by these models are evaluated and potential improvements suggested. A valuable single source of information, this book is recommended reading for neuroscientists as well as for neurologists and neurosurgeons interested in preclinical research on human neurological diseases.
Contents
Acknowledgment: Poindron, P.; Theoretical Considerations on Animal Models: Poindron, P.; Callizot, N.; Piguet, P.; Mouse Models with Motor Neuron Defects as a Tool for Deciphering Amyotrophic Lateral Sclerosis. Applications, Limits and Future Challenges: Echaniz-Laguna, A.; Fricker, B.; Fergani, A.; Loeffler, J.-P.; Rene, F.; A Chronic Relapsing Animal Model for Multiple Sclerosis. Myelin Oligodendrocyte Glycoprotein Induced Experimental Autoimmune Encephalomyelitis in Dark Agouti Rats: Kinter, J.; Zeis, T.; Schaeren-Wiemers, N.; Occlusion of the Middle Cerebral Artery in Rats. Refinement of an Animal Model for Human Stroke: Cam, E.; Kilic, E.; Yulug, B.; Ritz, M.-F.; Pyridoxine-Induced Peripheral Neuropathy. Animal Models and Uses: Callizot, N.; Poindron, P.; A Dopamine-Sensitive Inherited Motor Syndrome Linked to the frissonnant Mutation: Callizot, N.; Guenet, J.-L.; Poindron, P.; Author Index; Subject Index.
