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基本説明
Special Issue: Pathophysiology of Haemostasis and Thrombosis 2005, Vol. 34, No. 2-3.
Full Description
Blood coagulation, a complex system of enzymatic reactions responsible for hemostasis and thrombosis, has recently become a focus of active theoretical research. This publication is a first attempt to bring together mathematical modeling and computer simulation studies of various aspects of the coagulation system reported by leading laboratories in this field. A wide area of coagulation-related problems is considered, including control of the plasma coagulation cascade, threshold excitation of clotting, balance of coagulation and clot lysis, accuracy of deterministic and stochastic approaches to coagulation modeling, and effect of blood flow on thrombus formation. This special issue will be of interest to specialists in the biochemistry of blood coagulation, metabolic control, theoretical biology and bioinformatics. Applications of the described mathematical models and conclusions obtained can be useful in clinical practice and pharmaceutical design in hemostasis- and thrombosis-related areas.
Contents
Good Mathematical Practice: Simulation of the Hemostatic-Thrombotic Mechanism, a Powerful Tool but One That Must Be Used with Circumspection: Hemker, H.C.; Ataullakhanov, F.I.; Towards Virtual Coagulation: Ataullakhanov, F.I.; Panteleev, M.A.; Mathematical Modeling and Computer Simulation in Blood Coagulation: Ataullakhanov, F.I.; Panteleev, M.A.; Demonstration of a Threshold Response in a Proteolytic Feedback System: Control of the Autoactivation of Factor XII: Jesty, J.; Rodriguez, J.; Beltrami, E.; Stochastic Modeling of Blood Coagulation Initiation: Lo, K.; Denney, W.S.; Diamond, S.L.; Coagulation under Flow: The Influence of Flow-Mediated Transport on the Initiation and Inhibition of Coagulation: Fogelson, A.L.; Tania, N.; A Model for the Formation and Lysis of Blood Clots: Anand, M.; Rajagopal, K.; Rajagopal, K.R.; The Effect of Convective Flows on Blood Coagulation Processes: Lobanov, A.I.; Starozhilova, T.K.; Blood Coagulation and Propagation of Autowaves in Flow: Ermakova, E.A.; Panteleev, M.A.; Shnol, E.E.; Author Index; Subject Index.
