Full Description
This volume collects concise reviews by internationally-recognized clinicians and basic scientists working in all areas of major degenerative disease research. Inside are discussions and protocols which should help standardize the definitions, morphology and clinical aspects of Alzheimer's, Parkinson's, ALS and other dementias. This book should be useful to the clinical researcher who needs current, state-of-the-art viewpoints in neurodegeneration research.
Contents
Part 1 Normal ageing of the nervous system: definition of natural ageing, Barry Snow and Michael Cordes; molecular and neuroendocrine mechanisms in age-related astrocyte activities and neurodegeneration, C. Finch, et al; the natural history of ageing, P. Riederer and K.W. Lange; normal ageing of the nervous system, K.W. Lange and G.M. Paul. Part 2 Parkinson's disease: normality, disturbances and diseases, Donald B. Calne; the pre-clinical phase of Parkinson's disease, Werner Poewe; mitochondria in Parkinson's disease, yoshikuni Mizuno, et al; the biology of toxic events in Parkinson's disease, M.B.H. Youdim; markers for the presence and progression of Parkinson's disease, Peter A. Lewitt; discussion paper on Parkinson's disease, Fabrizio Stocchi. Part 3 Alzheimer's disease: definition of Alzheimer's disease, Elaine Perry and Robert Perry; morphology of the ageing brain and relations to Alzheimer's disease, Kurt A. Jellinger; natural history of Alzheimer's disease, Heiko Braak and Eva Braak; Alzheimer's disease discussion, K. Jendroska. Part 4 Amyotrophic lateral sclerosis: amyotrophic lateral sclerosis - clinical definition and relation to other neurodegenerative disorders, C.W. Olanow; pathogenic mechanisms in amyotrophic lateral sclerosis and otehr motor neuron disorders, P.N. Leigh; xenobiotic biochemistry of neurodegenerative disease with particular attention to methylation pathways, Adrian Williams; the natural history of amyotrophic lateral sclerosis - methodological considerations, Marinos C. Dalakas; amyotrophic lateral sclerosis - discussion, G. Ransmayr.
