Full Description
Cancer Immunology is intended as an up-to-date, clinically relevant review of cancer immunology and immunotherapy. This volume is focused on immunopathology of cancers. The interactions between cancerous cells and various components of the innate and adaptive immune system are fully described. The principal focus, however, is very much on clinical aspects, the aim being to educate clinicians in the clinical implications of the most recent research and new developments in the field. Over the past decade, understanding of the interactions between the immune system and cancerous cells has increased markedly, leading to the development of combinatorial immunotherapeutic strategies to combat cancer. This translational, clinically oriented book will be of special value to clinical immunologists, hematologists and oncologists.
Contents
Introduction on cancer immunology and immunotherapy.- Inflammatory and innate immune cells in cancer microenvironment and progression.- Role of innate immunity in cancers and antitumor response.- Role of B cells in anti tumor response.- The role of exhaustion in tumor-induced T cell dysfunction in patients with cancer.- Regulatory T cells and Th17 cells in the immunosuppressive tumor network.- Role of cytokines in tumor immunity and immune tolerance to cancers.- Role of chemokines and chemokine receptors in cancers.- The role of Fas and Fas-ligand in cancers.- MHC class I molecules and cancer progression: Lessons learned from preclinical tumor models.- Role of plasmacytoid dendritic cells in cancer.- Cancer immunoediting: immunosurveillance, immuneequilibrium, and immune escape.- Apoptosis, autophagy and necroptosis in Cancer.- Prognostic value of innate and adaptive immunity in cancers.- Epigenetics and Micro RNAs in cancers .- Immunogenetics of cancers.- Immunodeficiencies and cancers.- Immunosenescence and cancers.- Nutrition, immunity and cancers.- Allergies and cancers.- Cancer immunology of transmissible cancers.- Systems biology and systems immunology of cancer.- Principles of immunological diagnostic tests for cancers.- Flow cytometry in cancer immunotherapy: applications, analysis, quality control and future.- Immunohistochemistry of cancers.- Immunology and immunotherapy of graft versus host disease.
