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The present volume contains the proceedings of the 23rd Mos- bach Colloquium on "Protein-Protein Interactions". It includes the paper by Prof. S. LIFSON who unfortunately was unable to attend. Discussions were included whenever possible in order to make the complete proceedings accessible to the future reader. The colloquium was generously supported by the firms who are corporate members of the Gesellschaft fur Biologische Chemie. Dr. W. B. GRATZER and Dr. L. JAENICKE, as weIl as some of the invited speakers, were a tremendous help in preparing the program and we wish to thank them for their helpfuI suggestions and advice. Our appreciation extends to Prof. E. AUHAGEN and Prof. H. GIBIAN, and their secretaries, who shared the burden of organizing the colloquium. In addition, we wish to express our gratitude to Springer-Ver- Iag, and especially to Dr. H. MAYER-KAUPP for editoriaI help and for the rapid publication of this volume. We hope that the reader, Iike the audience in the Mosbach market hall, will gain an impression of the present state of protein research and of the way in which intermolecular interactions hold specific implications for the structure and function of proteins.
Regensburg and Wurzburg, autumn 1972 R. JAENICKE E. HELMREICH Contents Introduction. R. JAENICKE (Regensburg) 1 Molecular Forees. S. LIFSON (Rehovot) ...3 Structure, Function and Dynamics of a ReguIatory Enzyme: Aspartate Transcarbamylase. H. K. SCHACHMAN (Berkeley) 17 Discussion ...54 ...
Contents
Molecular Forces.- Structure, Function and Dynamics of a Regulatory Enzyme: Aspartate Transcarbamylase.- Discussion.- Quaternary Structure of Proteins.- Subunits to Superstructures: Assembly of Glutamate De-hydrogenase.- Subunit Interactions in Haemoglobin.- Approaches for Determining Protein Complexes.- Interaction between Chymotrypsin (Trypsin) and the Pancreatic Trypsin Inhibitor (Kallikrein Inactivator).- An Example of "Quasi-Irreversible" Protein-Protein Interaction: The Trypsin-Pancreatic Trypsin Inhibitor Complex.- Subunit Interactions in Lactate Dehydrogenase.- Cooperative Association.- Analysis of the Structure of Complex Proteins by Electron Microscopy.- Probe Studies on the Role of Protein-Protein Interactions and Enzyme Conformation in Control.- Enzyme-Enzyme Interactions in Tryptophan Synthetase from E. coli.- Heterologous Protein Interactions.- Heterologous Enzyme-Enzyme Interactions.- Influences of Heterologous Protein Interactions on the Control of Glycogen Phosphorylase.- Muscle.- Protein Assemblies in Muscle.- Multienzyme Complexes.- The Pyruvate Dehydrogenase Complex of E. coli K-12, Structure and Synthesis.- The Multienzyme Systems of Fatty Acid Biosynthesis.- Antigen-Antibody Interactions.- Conformational Changes in Protein Antigens Induced by Specific Antibodies: Sperm-whale Myoglobin.- Stabilization of Conformations of E. coli ?-Galactosidase by Specific Antibodies. Restrictions in Antigenic Determinants and Antibodies.- Self-Assembly.- TMV Protein Association and its Role in the Self-Assembly of the Virus.- Intercellular Interactions.- Surface Membrane Alterations and Relevance to Cell-Cell Interaction and Growth Control in Tissue Culture.- Concluding Remarks.
