NMR - From Spectra to Structures : An Experimental Approach (2004. X, 137 p. w. figs. 23,5 cm)

NMR - From Spectra to Structures : An Experimental Approach (2004. X, 137 p. w. figs. 23,5 cm)

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  • 製本 Paperback:紙装版/ペーパーバック版/ページ数 140 p.
  • 商品コード 9783540406952

Full Description

Nuclear magnetic resonance spectroscopy is one of the most important analytical methods available today. This practice-oriented textbook aims at teaching the use of NMR spectra in the elucidation of organic structures. The emphasis of NMR - from Spectra to Structures is on practical rather than on theoretical aspects, which are treated only briefly. The book is intended as a practical guide to today s standard NMR experiments for students and laboratory personnel. A set of thirty-five graded problems reinforces the reader s understanding of how problems of structure elucidation are solved by using NMR.

Table of Contents

Introduction                                       1 (2)
Part 1: NMR Experiments 3 (54)
1D Experiments 3 (33)
1H, D(2H): Natural Abundance, Sensitivity 3 (19)
Proton NMR Spectrum of the Model 4 (4)
Compound 1
Field Dependence of the Spectrum of 1 8 (2)
FID Manipulation: FT, EM, Sine Bell 10(2)
(CH2 signal of 1)
The proton spectrum of 1 in D2O or 12(2)
H2O/D2O mixtures
Integration: Relaxation, T1, 14(4)
90°-Pulse, Ernst Angle
The NOE: Through-Space Interactions 18(1)
between Protons
NOE Difference Spectroscopy 19(1)
Selective 1D NOE Experiment 20(2)
13C 22(12)
Natural Abundance Carbon-13 Spectrum of 22(2)
Compound 1
Coupled Spectrum (Gated Decoupling) 24(2)
Quantitative 13C Spectrum (Inverse 26(1)
Gated Decoupling)
Decoupled Spectrum: Proton Decoupling, 26(2)
Proton and Phosphorus Decoupling
The Inadequate Experiment 31(3)
31p 34(2)
Natural Abundance Phosphorus-31 34(1)
Spectrum of Compound 6
Proton-Decoupled and Proton-Coupled 34(1)
Coupled Spectrum (P-P Coupling) 34(2)
2D Experiments 36(12)
General Principles, Inverse Techniques, 36(2)
H,H Cosy 38(2)
2D Noe 40(2)
P,H Cosy: With Varying Mixing Times for 42(1)
the Coupling
C,H Direct Correlation 43(1)
C,H Long Range Correlation 44(2)
P,C Correlation 46(1)
P,P Correlation 47(1)
Quadrupolar Nucleus Experiments 48(2)
General Principles: Quadrupole Moment, 48(1)
Relaxation, Linewidth
17O 49(1)
17O Spectrum of 7: Chemical Shift 49(1)
(Reference), Coupling with P
P-O Correlation 50(1)
HPLC-NMR Coupling 50(7)
General Principles, NMR as a Highly 50(1)
Sensitive Analytical Tool (μg to ng
Example: Separation of 4 and 5, two 51(1)
Acetals of Formylphosphonic Ester
Chromatogram 52(1)
On-flow Diagram (Chemical Shift vs. Time) 53(2)
Stopped Flow Experiments 55(2)
Appendix: Reference List 57(2)
Part 2: Worked Example and Problems 59(1)
Introduction 59(3)
Worked Example 62(5)
Problems 67