基本説明
Gives a representative survey of the current status of the structure, function, regulation and molecular pharmacology of Neurotransmitter Transporters.
Full Description
The present volume of the Handbook of Experimental Pharmacology gives a representative survey of the current status of the structure, function, regulation and molecular pharmacology of Neurotransmitter Transporters and aims at providing an overview of insights that were generated in the past 5 years. If the volume serves as both, a useful compendium of current concepts and an inspiring starting point, it will have fulfilled its mission and will be a source for students interested in this emerging field as well as for experienced scientists looking for an update. This volume is the brainchild of the editor-in-chief of the HEP series, Klaus Starke, awe-inspiring to all pharmacologists of younger generations.
Contents
Zn2+ Modulation of Neurotransmitter Transporters.- Molecular Microfluorometry: Converting Arbitrary Fluorescence Units into Absolute Molecular Concentrations to Study Binding Kinetics and Stoichiometry in Transporters.- Structure/Function Relationships in Serotonin Transporter: New Insights from the Structure of a Bacterial Transporter.- The Importance of Company: Na+ and Cl? Influence Substrate Interaction with SLC6 Transporters and Other Proteins.- Currents in Neurotransmitter Transporters.- Mutational Analysis of Glutamate Transporters.- The Diverse Roles of Vesicular Glutamate Transporter 3.- Extraneuronal Monoamine Transporter and Organic Cation Transporters 1 and 2: A Review of Transport Efficiency.- The Role of SNARE Proteins in Trafficking and Function of Neurotransmitter Transporters.- Regulation of the Dopamine Transporter by Phosphorylation.- The Dopamine Transporter: A Vigilant Border Control for Psychostimulant Action.- Oligomerization of Neurotransmitter Transporters: A Ticket from the Endoplasmic Reticulum to the Plasma Membrane.- Acute Regulation of Sodium-Dependent Glutamate Transporters: A Focus on Constitutive and Regulated Trafficking.- Regulation and Dysregulation of Glutamate Transporters.- Regulation of Vesicular Monoamine and Glutamate Transporters by Vesicle-Associated Trimeric G Proteins: New Jobs for Long-Known Signal Transduction Molecules.- Human Genetics and Pharmacology of Neurotransmitter Transporters.- ADHD and the Dopamine Transporter: Are There Reasons to Pay Attention?.- Inactivation of 5HT Transport in Mice: Modeling Altered 5HT Homeostasis Implicated in Emotional Dysfunction, Affective Disorders, and Somatic Syndromes.- Lessons from the Knocked-Out Glycine Transporters.- The Norepinephrine Transporter in Physiology and Disease.-The High-Affinity Choline Transporter: A Critical Protein for Sustaining Cholinergic Signaling as Revealed in Studies of Genetically Altered Mice.
