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Full Description
This edited book is a compilation of findings on the molecular and cellular toxicity of nanoparticles (NPs) in animal cell, human cells, invertebrates. The varied selection of test models will provide better understanding about the horizon of NPs toxicity. Interaction of NPs with cells and its organelles can induce toxicological consequences, including transcriptional and translational alterations, DNA damage, cytotoxicity, oxidative stress, mitochondrial dysfunction and cell death. NPs can get internalized in cells through phagocytosis, macropinocytosis, receptor-mediated endocytosis and passive penetration, which can affect varied cell types.
Readers will be benefited with the compilations on basic and molecular facet of NPs toxicity. The chapters will provide a comprehensive information on the state-of-the-art methodologies. The application of toxicogenomic approaches, which is already established in nanotoxicology, has been given special consideration to unravel the toxicodynamics of nanomaterials. Among these approaches, the high-throughput RNA sequencing (RNA-Seq), which is able to build a complete map of transcriptome across different cell types and perturbations upon NPs exposure has been included. The readers are also introduced to the less studied topic on the adsorption of biomolecules (mainly proteins) on the NPs surface, constituting the so-called "biomolecular corona".
The book has been designed for scientists engaged in NPs toxicity research. Nonetheless, it should be of interest to a variety of scientific disciplines including marine biology, environmental pollution, genetics, pharmacology, medicine, drug and food material sciences, consumer products. Also, the compilations will be of interest to the environmental watchdogs, federal regulators, risk assessors and the policy makers.
Contents
Toxicity Assessment in The Nanoparticle Era.- Mechanisms of Uptake and Translocation of Nanomaterials in the Lung.- Transmucosal Nanoparticles: Toxicological Overview.- The Toxicity of Nanoparticles to Human Endothelial Cells.- The Role of Autophagy in Nanoparticles-Induced Toxicity and its Related Cellular and Molecular Mechanisms.- Nanoparticles-Caused Oxidative Imbalance.- Toxicity of Metal Oxide Nanoparticles.- Relevance of Physicochemical Characterization of Nanomaterials for Understanding Nano-Cellular Interactions.- Toxicogenomics: A New Paradigm for Nanotoxicity Evaluation.- Nickel Oxide Nanoparticles Induced Transcriptomic Alterations in HepG2 Cells.- Nanoparticle-Protein Interaction: The Significance and Role of Protein Corona.- Cellular and Molecular Toxicity of Iron Oxide Nanoparticles.- Detection of DNA Damage Induced by Cerium Dioxide Nanoparticles: From Models to Molecular Mechanism Activated.- Mechanisms Underlying Neurotoxicity of Silver Nanoparticles.- Toxic and Beneficial Potential of Silver Nanoparticles: The Two Sides of the Same Coin.- Molecular and Cellular Toxicology of Nanomaterials with Related to Aquatic Organisms.- Cytotoxicity and Physiological Effects of Silver Nanoparticles on Marine Invertebrates.- A Drosophila Model to Decipher the Toxicity of Nanoparticles Taken Through Oral Routes.- Using of Quantum Dots in Biology and Medicine.
