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Full Description
Under the generous chairmanship of Professor Dr. med. Werner Kaufmann we organized the international symposium on "VASODEPRESSOR HORMONES IN HYPERTENSION - PROSTAGLANDINS AND KININS" held in Nuremberg (FRG) as an official satellite symposium to the Meeting of the International Society of Hypertension 1986. This supplement brings together the most interesting papers presented at this symposium. In the past there were hundreds of publications in both fields, the prostaglandins and the kallikrein-kinins and there were a lot of information indic‾ting that these two systems influence each other strongly. But it is not at all clear till today which role these two systems play in physiological or even pathophysio logical regulation of systemic blood pressure. So it was aim of this symposium to bring the scientists of these two fields together to discuss blood pressure regulation in respect of the prostaglandin and kallikrein-kinin system. The authors of the presented papers provided new findings, an overview of their own work, and their hypotheses in this field. We would like to thank the contributors for their excellent papers and scientific discussion. We pay particular credit to the Birkhauser Verlag AG, Basel, Switzerland, for their kind cooperation, and express particular thanks to Mrs Renate Wiesmann and Mrs Renate Cawello for writing the manuscripts. Our gratitude goes to Schwarz GmbH, Monheim (FRG) wi thout their sponsorship this symposium' and book would not have been possible. July, 1987 G. Bonner O. A. Carretero H. Kueppers J.
Contents
Prostaglandins.- Renal cytochrome P450-dependent oxygenation of arachidonic acid.- The regulation of Prostaglandins by vasoactive hormones in renal tubular and vascular smooth muscle cells.- Inhibitory effect of sulindac on prostaglandin synthesis in cultured renal and vascular cells.- Arachidonate cascade in mesenteric blood vessels and platelets of spontaneously rats.- Effect of in vitro aging on prostaglandin synthesis in cultured rat vascular smooth muscle cells.- Effects of angiotensin I converting enzyme (ACE) related substances upon the vascular prostacyclin generation.- The role of renal prostaglandins in the regulation of renal sodium excretion.- Vasodepressor lipid of the renomedullary interstitial cells of the renal papilla is a prohormone activated by the liver.- Vasodepressor phospholipids in reversal of renal hypertension.- Role of renal nerves and dopamine on prostaglandin E release from the kidney of rats.- Effects of altered prostanoid and lyso-PAF synthesis by marine oil diets on blood pressure of salt loaded spontaneously hypertensive rats.- Role of prostaglandin and angiotensin II in ANP- induced natriuresis.- The endothelium and cyclic guanosine monophosphate in hyperthyroid-induced hypertension.- Role of the prostaglandin-thromboxane system in the development and maintenance of spontaneous hypertension in the rat.- Potassium supplementation lowers blood pressure in spontaneously hypertensive rats - relationships with urinary prostaglandins and renin.- Effect of pregnancy on plasma renin activity and glomerular synthesis of protaglandins and thromboxane in rats.- The role of prostaglandins in the chronic regulation of renal function and renal adaptation to protein diet.- Reduced excretion of vasodilator prostaglandins in preeclampsia.- Inhibition ofprostaglandins and angiotensin II: effects on renal function in hypertensive patients.- Humoral changes during a long-term antihypertensive treatment.- The role of renal dopamine and PGE in mediating the renal effects of the antihypertensive loop diuretic piretanide.- Renal production of prostaglandin E2 is not deficient in essential hypertension.- Interactions of renal prostaglandins, renin-angiotensin system and renal kallikrein-kinin system in human hypertension.- Kallikrein-Kinin System.- Biochemistry of human tissue (urinary) kallikrein.- Interaction of calcium ion and atrial natriuretic peptide on blood pressure, natriuresis and the renal kallikrein-kinin system in anesthetized rabbits.- The pathophysiological role of renal dopamine, kallikrein kinin and prostaglandin systems in essential hypertension.- Relationship between urinary kallikrein excretion and the extent of circulating inactive renin activation by the kidney.- T-Kininogen in rat plasma after nephrectomy and other surgical traumas.- Direct radioimmunoassay for rat high molecular weight kininogen Measurement of immunoreactive high molecular weight kininogen in normal and kininogen deficient plasma.- Cleavage of peptide bonds by angiotensin I converting enzyme.- Measurement of circulating kinins, their changes by inhibition of kininase II and their possible blood pressure lowering effect.- Diminution by captopril of the diuretic, natriuretic and kallikrein stimulating action of furosemide by reduction in its renal secretion.- Urinary kallikrein excretion can predict the blood pressure response to a single oral dose of captopril.- Low urinary excretion of active and total kallikrein in developing spontaneously hypertensive rats and effect of long term converting enzyme inhibition.- Changes of angiotensinconverting enzyme (ACE) levels during activation of the renin-angiotensin-aldosterone system (RAAs).- Lack of a role of circulating bradykinin in the blood pressure response to acute angiotensin converting enzyme inhibition in rats.- The antihypertensive contribution of bradykinin as assessed by a specific bradykinin antagonist.- Regulation of inactive renin secretion: studies with aprotinin.- The effects of aprotinin, a glandular kallikrein inhibitor, on renin release and urinary sodium excretion in mild essential hypertensives..- In vivo assay of specific kallikrein inhibitors.
