Full Description
This first book to adopt a problem-based approach teaches the true basics of the subject through illustrated everyday case studies. The editor's extensive experience in writing textbooks and his close relationship to the authors ensure that the contributions are presented in a pedagogically uniform and highly motivating fashion. Each chapter introduces a different biological problem taken from everyday lab work, such that students learn how to think in order to solve problems in biology by using techniques and tools taken from chemistry.
A must-have for students in chemistry, biology and biochemistry.
Contents
YEAST-BASED CHEMICAL GENOMIC APPROACHES
Introduction
The Biological Problem
The Chemical Approach
Chemical Biological Research/Evaluation -
Chemogenomic Profiling: Elucidating the Mode of Action of Small Molecules
MIRCOARRAY-BASED STRATEGIES TO IDENTIFY UNKNOWN PROTEIN INTERACTIONS
Introduction
The Biological Problem
The Chemical Approach
Chemical Biological Research/Evaluation
COMPOUND COLLECTION SYNTHESIS FOR CHEMICAL BIOLOGY
Introduction
Chemical Probes -
A Chemical Question with Biological Consequences
Diversity Oriented Synthesis (DOS)
Biology Oriented Synthesis (BIOS)
TARGET IDENTIFICATION AND VALIDATION OF A WNT/BETA-CATENIN PATHWAY MODULATOR
Introduction
Introduction
The Biological Problem
The Chemical Approach
Chemical Biological Research/Evaluation
ACTIVITY-BASED PROTEIN PROFILING OF CYS PROTEASES
Introduction
The Biological Problem
The Chemical Approach
Chemical Biological Research/Evaluation
THE USE OF PHOTOAFFINITY LABELING FOR THE IDENTIFICATION OF THE BINDING SITE OF THE ANTIBIOTIC LINEZOLID
Introduction
The Biological Problem
The Chemical Approach
Chemical Biological Research/Evaluation
SURGICAL STRIKES: USES OF ANALOG SENSITIVE TECHNOLOGIES TO TARGET KINASES OF INTEREST
Introduction
The Biological Problem
The Chemical Approach
Chemical Biological Research/Evaluation: ASKA Technology -
Applications in Molecular Biology
MODULATION OF PROTEIN-PROTEIN INTERACTIONS BY SMALL MOLECULES
Introduction
The Biological Problem
The Chemical Approach
Chemical Biological Research/Evaluation
TARGETED PROTEIN DEGRADATION IN LIVE CELLS
Introduction
The Biological Problem
The Chemical Approach
TRAPOXIN B: FROM TOTAL SYNTHESIS TO EPIGENETICS
Introduction
The Biological Problem
The Chemical Approach
Chemical Biological Research/Evaluation
NATIVE CHEMIAL LIGATION -
A TOOL FOR CHEMICAL PROTEIN SYNTHESIS
Introduction
The Synthetic Challenge
The Chemical Approach -
Native Chemical Ligation
Chemical Biological Research/Evaluation -
The Ras-RBD Systems
USING SPLIT INTEINS TO PREPARE SEMI-SYNTHETIC PROTEINS AND TO STUDY THE MECHANISMS OF PROTEIN TRANS-SPLICING
Introduction
The Biological Problem
The Chemical Approach
Chemical Biological Research/Evaluation
ELUCIDATION OF THE RAS CYCLE WITH SEMI-SYNTHETIC PROTEINS
Introduction
The Biological Problem
The Chemical Approach
Chemical Biological Research/Evaluation
THE STUDY OF RAB GTPASE RECYCLING USING SEMI-SYNTHETIC PRENYLATED PROTEINS
Introduction
The Biological Problem
The Chemical Approach
Chemical Biological Research/Evaluation
DEVELOPMENT OF A MODEL CANCER VACCINE CANDIDATE BASED ON THE MUCl CELLULAR SURFACE GLYCOPEPTIDE EPITOPE
Introduction
The Biological Problem
The Chemical Approach
Chemical Biological Research/Evaluation
THE INTRODUCTION OF CHEMICAL REPORTER GROUPS BY BIOORTHOGONAL LIGATION REACTIONS FOR THE IMAGING OF CELL-SURFACE GLYCANS
Introduction
The Biological Problem
The Chemical Approach
Chemical Biological Research/Evaluation
SEQUENCE SPECIFIC DNA-BINDING SMALL MOLECULES FOR PROTEIN RECRUITMENT AND MODULATION OF TRANSCRIPTION
Introduction
The Biological Problem -
Targeting DNA with Small Molecules
The Chemical Approach: The Polyamide Rationale
Chemical Biological Research/Evaluation -
Polyamides in Biological Applications
G-QUADRUPLEX LIGANDS AS TOOLS FOR ELUCIDATING C-MYC TRANSCRIPTIONAL REGULATION
Introduction
The Biological Problem
The Chemical Approach
Chemical Biological Research/Evaluation
