Full Description
This book is a comprehensive review of the recent research on the lipotoxicity-related mechanisms in obesity and the development of new treatment strategies. In this second edition, the possible molecular treatment methods and their recent clinical approaches are discussed in addition to the basic mechanisms that are available and thoroughly reviewed previously. Moreover, all chapters have been reviewed, according to the current concepts and seven new chapters are added, covering obesity-related epigenetic modifications, senescence, obesity-related cancer development, endocrine disruptors, as well as nanotechnology-based clinical approaches.
This book is an essential resource for clinicians and basic science researchers, such as biochemists, toxicologists, immunologists, nutritionists, adult and pediatric endocrinologists, and cardiologists, as well as all researchers or students who want to learn the mysteries of obesity.
Contents
Chapter 1. The Definition and prevalence of obesity and metabolic syndrome.- Chapter 2. Circadian rhythms in diet-induced obesity.- Chapter 3. Eating and death: Chronic over-eating.- Chapter 4. New insights in the link between melanoma and obesity.- Chapter 5. Human Protein kinases and obesity.- Chapter 6. Fat cell and fatty acid turnover in obesity.- Chapter 7. Adipose tissue function and expandability as determinants of lipotoxicity and metabolic syndrom.- Chapter 8. What is lipotoxicity.- Chapter 9. The pathogenesis of obesity-associated adipose tissue inflammation.- Chapter 10. Microbiota and lipotoxicity.- Chapter 11. Endoplasmic reticulum stress and obesity.- Chapter 12. Insulin resistance, obesity and lipotoxicity.- Chapter 13. Adipose tissue hypoxia in obesity and its impact on preadipocytes and macrophages: Hypoxia hypothesis.- Chapter 14. Adipocyte-macrophage cross-talk in obesity.- Chapter 15. Endothelial dysfunction in obesity.- Chapter 16. Diet-induced obesity and the mechanism of leptin resistance.- Chapter 17. Influence of antioxidants on leptin metabolism and its role in the pathogenesis of obesity.- Chapter 18. Adiponectin-resistance in obesity.- Chapter 19. Non-alcoholic fatty liver disease.- Chapter 20. Lipotoxicity-related hematologic disorders in obesity.- Chapter 21. Micro-RNA and Adipogenesis: Impact of epigenomic and mutational regulation of diet-induced obesity.- Chapter 22. The interactions between kynurenine,folate, methionine and pteridine pathways in obesity.- Chapter 23. Eligibility and success criteria for bariatric/metabolic surgery.-Chapter 24. Does bariatric surgery improve lipotoxicity-associated comorbid conditions.- Chapter 25. Obesity-associated breast cancer: analysis of risk factors.- Chapter 26. Lipotoxicity in obesity: Benefit of olive oil.- Chapter 27. The checkpoints of intestinal fat absorption in obesity.- Chapter 28. Next-cell hypothesis: Mechanism of obesity-associated carcinogenesis.- Chapter 29. Targeted nano-based systems for the anti-obesity agents' delivery.- Chapter 30. Macrophage activation syndrome in coinciding pandemics of obesity and COVID-19: Worse than bad.
