Full Description
This book discusses the role of oxidative stress in human reproduction with a focus on men's health. The physiological roles of reactive oxygen species (ROS) in male fertility are the focus in this book. This topic is important because oxidative stress is a result of the imbalance between ROS and antioxidants in the body which may lead to sperm damage (DNA or count), deformity, and eventually, male infertility. Therefore, for a better understanding of the molecular mechanisms related to male genotoxicity and its regulation in infertility, this book provides an up-to-date view on the impact of oxidative stress factors in male reproduction .
The main aim of this book is to collect a series of research articles and reviews from a diverse group of scientists to share their research work on the role of ROS or oxidative stress in physiological and pathological states in relation to (in)fertility in the male. This book presents various state-of-the-art chapters of the recent progress in the field of cellular toxicology and clinical manifestations of various issues related to men's health and fertility. Topics include cell signaling, DNA damage and infertility, the pathophysiology of disease instigation and distribution, immune toxicity and prevention.
Contents
Oxidative stress and toxicity in reproductive biology and medicine: Historical perspectives and future horizons in male fertility.- Reactive Oxygen Species in the Reproductive System: Sources and Physiological Roles.- Pathological Roles of Reactive Oxygen Species in Male Reproduction.- Molecular Interactions Associated with Oxidative Stress Mediated Male Infertility: Sperm and Seminal Plasma Proteomics.- Unraveling the Molecular Impact of Sperm DNA Damage on Human Reproduction.- Role of Infection and Leukocytes in Male Infertility.- Bacteriospermia and Male Infertility: Role of Oxidative Stress.- Oxidant-Sensitive Inflammatory Pathways and Male Reproductive Functions.- Oxidative Stress and Idiopathic Male Infertility.- Oxidative Stress and Varicocele-Associated Male Infertility.- Oxidative Stress in Men with Obesity, Metabolic Syndrome and Type 2 Diabetes Mellitus: Mechanisms and Management of ReproductiveDysfunction.- Metabolic dysregulation and sperm motility in male infertility.- Tale of viruses in male infertility.- Pathogenesis of Viral Infections and Male Reproductive Health: An Evidence-Based Study.- Sperm redox system equilibrium: Implications for fertilization and male fertility.
