The Role of Toll-Like Receptor 4 in Infectious and Non Infectious Inflammation (Progress in Inflammation Research)

個数：

The Role of Toll-Like Receptor 4 in Infectious and Non Infectious Inflammation (Progress in Inflammation Research)

Rossetti, Carlo (EDT)/ Peri, Francesco (EDT)

ウェブストア価格 ¥22,559（本体¥20,509）
Springer Nature Switzerland AG（2021/11発売）
外貨定価 US$ 109.00
ポイント 205pt

オンデマンド(OD/POD)版です。キャンセルは承れません。

【入荷遅延について】
世界情勢の影響により、海外からお取り寄せとなる洋書・洋古書の入荷が、表示している標準的な納期よりも遅延する場合がございます。
おそれいりますが、あらかじめご了承くださいますようお願い申し上げます。

◆画像の表紙や帯等は実物とは異なる場合があります。

◆ウェブストアでの洋書販売価格は、弊社店舗等での販売価格とは異なります。
また、洋書販売価格は、ご注文確定時点での日本円価格となります。
ご注文確定後に、同じ洋書の販売価格が変動しても、それは反映されません。

製本 Paperback:紙装版/ペーパーバック版／ページ数 174 p.
商品コード 9783030563219

Full Description

TLR4 is one of the most important innate immunity receptors, its function mainly consisting in the activation of inflammatory pathways in response to stimulation by Pathogen-Associated Molecular Patterns (PAMPs) and Damage Associated Molecular Pattern molecules (DAMPs).

This volume critically reviews the different types of TLR4 activators and inhibitors, discusses the role of molecular aggregates in agonism/antagonism as well as the pivotal role of the CD14 receptor in the modulation of TLR4 signal and the molecular details and actors of the intracellular cascade.

The book presents the role of TLR4 in several pathologies, such as sepsis and septic shock caused by receptor activation by gram-negative bacterial lipopolysaccharide (LPS), in neurodegenerative and neurological diseases such as Parkinson and Alzheimer's diseases, and Amyotrophic Lateral Sclerosis (ALS). It reviews the role of TLR4 in neural stem cell-mediated neurogenesis andneuroinflammation and in Human Induced Pluripotent Stem Cells and Cerebral Organoids and discusses the emerging role of micro-RNA (miRNA) regulation by TLR4.

Chapter 1. Chemically synthesized TLR4 ligands, their immunological functions and potential as vaccine adjuvant.- Chapter 2. Intracellular TLR4 signaling.- Chapter 3. TLR4 Ligands: Single Molecules and Aggregates.- Chapter 4. CD14: not just chaperone, but a key-player in inflammation.- Chapter 5. Toll-Like Receptor 4 interactions with Neisseria.- Chapter 6. Toll-Like Receptor4 and Damage-Associated Molecular Patterns (DAMPS).- Chapter 7. TLR4 in neurodegenerative diseases: Alzheimer and Parkinson disease.- Chapter 8. TLR4-mediated Neuroinflammation in Human Induced Pluripotent Stem Cells and Cerebral Organoids.- Chapter 9. The role of TLR4 in neural stem cells-mediated neurogenesis and neuroinflammation.- Chapter 10. Toll-Like Receptor 4 and the world of microRNAs.- Chapter 11. Metabolic reprogramming of myeloid cells upon TLR4 stimulation.