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The number of people living with dementia is expected to rise from 55 million in 2019 to 139 million in 2050, according to a report by WHO. Treatments and potential cures for Alzheimer's have been researched for a long time now. Conventional drugs, while providing symptomatic relief, have often fallen short of halting the relentless progression of this neurodegenerative disorder. This new two-volume set, Neuro-Nutraceuticals and Drug Discovery and Delivery in Alzheimer's Disease, 2-volume set, represents a collective effort to delve into the potential of nature's pharmacopeia in our battle against Alzheimer's disease. The editors posit that essential insights into the intricacies of the disease are the foundation for subsequent discussions on potential therapeutic interventions.
Volume 1: Targeting Key Pathological Pathways first lays the foundation by unveiling the underlying pathological, biochemical, molecular, and genetic aspects of Alzheimer's disease. These chapters provide essential insights into the intricacies of the disease and serve as a springboard for the subsequent discussions on potential therapeutic interventions. Chapters cover pathophysiology and diagnosis, the connection of gut microbiome and Alzheimer's disease, drug-induced Alzheimer's disease, and more. The volume then goes on to shine a spotlight on the vast potential of nutraceuticals in managing Alzheimer's disease. It explores a plethora of medicinal plants and their secondary metabolites that show promise in treating this devastating condition. From preclinical findings to clinical studies, the chapters present a wealth of knowledge on memory improvement effects and the mechanisms underlying the actions of these neuro-nutraceuticals. Covered are the role of diet, micronutrients, and macronutrients in managing Alzheimer's disease; Medhya Rasayana (medicinal plants described in the Indian system of medicine that are said to improve memory and intellect); nootropics (also known as drug cognitive enhancers that help to improve memory, increase mental alertness and concentration as well as boost energy levels and wakefulness); and other ethnopharmacological approaches for dementia.
Volume 2: Strategies to Unlock the Brain's Fortress offers a comprehensive exploration into the cutting-edge strategies for the pursuit of effective Alzheimer's management. The first section of this volume is dedicated to a holistic exploration of nutraceuticals and their pivotal role in managing Alzheimer's disease, serving as a guide to the diverse array of neuro-nutraceuticals and providing insights into their mechanisms, efficacy, and potential integration into holistic Alzheimer's management strategies. The chapter authors look at natural antioxidant therapeutics, natural steroidal phytopharmaceuticals and Terpenes (aromatic compounds found in many plants), anti-apoptotic natural products, polysaccharides, neuro-protective role of vitamin D, non-flavonoidal agents for the effective treatment of Alzheimer's. Recent developments and advancements in the delivery of nutraceuticals are explored as well, looking at nanotechnology and advanced drug delivery systems for therapeutic interventions in Alzheimer's disease.
Together, these volumes not only reflect the current state of knowledge but also pave the way for future exploration in the field. Neuro-Nutraceuticals and Drug Discovery and Delivery in Alzheimer's Disease will enlighten readers, whether seasoned researchers, practitioners, or advanced students, with a wealth of scientific knowledge gained through the cutting-edge research and in-depth exploration of the therapeutic potential of nature's offerings and shall contribute to the ongoing efforts in managing dementia and cognitive disorders.
Contents
VOLUME 1: TARGETING KEY PATHOLOGICAL PATHWAYS PART I: MOLECULAR AND GENETIC PATHWAYS IN ALZHEIMER'S DISEASE 1. Pathophysiology and Diagnosis of Alzheimer's Disease: Past and Recent Developments 2. Tangled Connection of Gut Microbiome and Alzheimer's Disease 3. Epigenetic Modifications in Alzheimer's Disease 4. Drug-Induced Alzheimer's Disease 5. The Road to Drug Discovery Targeting Abnormal Proteins: Taking a Glance at Alzheimer's Treatments Through Rose-Colored Glasses 6. Preclinical Testing Methods for Evaluation of Potential Anti-Alzheimer's Drugs PART II: NUTRACEUTICALS FOR THE MANAGEMENT OF ALZHEIMER'S DISEASE 7. Medhya Rasayanas for the Management of Alzheimer's Disease 8. Management of Alzheimer's Disease in the Light of Ayurveda 9. Nootropics: Traditional Medicinal Prospective 10. Ethnopharmacological Approaches for Dementia 11. Role of Diet, Micronutrients, and Macronutrients in Managing Alzheimer's Disease VOLUME 2: STRATEGIES TO UNLOCK THE BRAIN'S FORTRESS PART I: NUTRACEUTICALS: HOLISTIC APPROACHES TO ALZHEIMER'S MANAGEMENT 1. Emergent Natural Antioxidant Therapeutics to Cope with Oxidative Stress in Alzheimer's Disease 2. Exploring Beta Secretase Inhibitors as the Evergreen Drug Target for Alzheimer's Disease: Calling Herbal Therapies to the Rescue 3. Role of Natural Steroidal Phytopharmaceuticals in the Management of Alzheimer's Disease 4. Potential Role of Terpenes in the Management of Alzheimer's Disease 5. Anti-Apoptotic Natural Products for the Management of Alzheimer's Disease 6. Potential Natural Polysaccharides for the Management of Alzheimer's Disease 7. Neuro-Protective Role of Vitamin D in Alzheimer's Disease 8. Role of Non-Flavonoidal Agents in Alzheimer's Disease PART II: RECENT DEVELOPMENTS AND ADVANCEMENTS IN THE DELIVERY OF NUTRACEUTICALS ACROSS BLOOD-BRAIN-BARRIER 9. Drug Delivery Strategies for Drug Targeting for Alzheimer's Disease 10. Nanocargos for Efficient Delivery of Nutraceuticals Across Blood-Brain Barrier 11. Recent Advancement in Strategies for Delivery of Neuronutraceuticals to the Brain
