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Full Description
Tight junction proteins connect epithelial and endothelial cells and, importantly, form selective barriers and channels for paracellular transportation. Two types of tight junction proteins—the claudin family (claudins-1 to -27) and the TAMP family (occludin, Marvel-D2, and tricellulin)—can be distinguished molecularly and functionally. Recent work has focused on delineating the functional significance of differences in selective permeability, for example, by examining the regulatory mechanisms of tight junctions. This work is of great clinical importance as many inflammatory or infectious diseases are characterized by increased permeability and the manipulation of tight junctions presents a new horizon in the development of novel therapeutics. The volume Barriers and Channels Formed by Tight Junction Proteins II provides a detailed look at the recent advances in our understanding of tight junction regulation and dysregulation. The papers included focus on three major themes: inflammation and gastrointestinal function; epithelial transport, barrier modulation, and food components; and tight junctions in intestinal and renal epithelia.
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Contents
TNF-[alpha]-induced intestinal epithelial cell shedding : implications for intestinal barrier function / Alastair J.M. Watson and Kevin R. Hughes Tight junctions on the move : molecular mechanisms for epithelial barrier regulation / Le Shen
HIV infection and the intestinal mucosal barrier / Hans-Jörg Epple and Martin Zeitz
Zonulin, regulation of tight junctions, and autoimmune diseases / Alessio Fasano
Myosin light chain kinase : pulling the strings of epithelial tight junction function / Kevin E. Cunningham and Jerrold R. Turner
Defective tight junctions in refractory celiac disease / Michael Schumann [and others]
Microbial butyrate and its role for barrier function in the gastrointestinal tract / Svenja Plöger [and others]
SUMOylation of claudin-2 / Christina M. Van Itallie, Laura L. Mitic and James M. Anderson
Proof of concept for claudin-targeted drug development / Hidehiko Suzuki [and others]
Loss of enteral nutrition in a mouse model results in intestinal epithelial barrier dysfunction / Yongjia Feng [and others]
The protein C pathway in intestinal barrier function : challenging the hemostasis paradigm / Silvia D'Alessio, Marco Genua and Stefania Vetrano
Analysis of absorption enhancers in epithelial cell models / Rita Rosenthal [and others]
Calcium regulation of tight junction permeability / Markus Bleich, Qixian Shan and Nina Himmerkus
Effects of quercetin studied in colonic HT-29/B6 cells and rat intestine in vitro / Maren Amasheh [and others]
Claudin-based paracellular proton barrier in the stomach / Atsushi Tamura [and others]
Regulation of epithelial proliferation by tight junction proteins / Attila E. Farkas, Christopher T. Capaldo and Asma Nusrat
Barrier dysfunction and bacterial uptake in the follicle-associated epithelium of ileal Crohn's disease / Åsa V. Keita and Johan D. Söderholm
The protozoan pathogen Toxoplasma gondii targets the paracellular pathway to invade the intestinal epithelium / Caroline M. Weight and Simon R. Carding
Ion transport and barrier function are disturbed in microscopic colitis / Christian Barmeyer [and others]
Enteropathogenic E. coli effectors EspG1/G2 disrupt tight junctions : new roles and mechanisms / Lila G. Glotfelty and Gail A. Hecht
Abnormal intestinal permeability in Crohn's disease pathogenesis / Christopher W. Teshima, Levinus A. Dieleman and Jon B. Meddings
A dynamic paracellular pathway serves diuresis in mosquito Malpighian tubules / Klaus W. Beyenbach
Impaired paracellular ion transport in the loop of Henle causes familial hypomagnesemia with hypercalciuria and nephrocalcinosis / Lea Haisch and Martin Konrad
The yin and yang of claudin-14 function in human diseases / Jianghui Hou
