Full Description
Iron Physiology and Pathophysiology in Humans provides health professionals in many areas of research and practice with the most up-to-date and well-referenced volume on the importance of iron as a nutrient and its role in health and disease. This important new volume is the benchmark in the complex area of interrelationships between the essentiality of iron, its functions throughout the body, including its critical role in erythropoiesis, the biochemistry and clinical relevance of iron-containing enzymes and other molecules involved in iron absorption, transport and metabolism, he importance of optimal iron status on immune function, and links between iron and the liver, heart, brain and other organs. Moreover, the interactions between genetic and environmental factors and the numerous co-morbidities seen with both iron deficiency and iron overload in at risk populations are clearly delineated so that students as well as practitioners can better understand the complexities of these interactions.
Key features of the volume include an in-depth index and recommendations and practice guidelines are included in relevant chapters. The volume contains more than 100 detailed tables and informative figures and up-to-date references that provide the reader with excellent sources of information about the critical role of iron nutrition, optimal iron status and the adverse clinical consequences of altered iron homeostasis. Iron Physiology and Pathophysiology in Humans is an excellent new text as well as the most authoritative resource in the field.
Contents
Proteins of Iron Homeostasis.- Cellular Iron Physiology.- Regulation of Cellular Iron Metabolism in Mammalian Cells.- Concentrating, Storing and Detoxifying Iron: The Ferritins and Hemosiderin.- Iron Nutrition.- Intestinal Iron Absorption.- Plasma Iron and Iron Delivery to the Tissues.- Iron Salvage Pathways.- Molecular Regulation of Systemic Iron Metabolism.- Erythroid Iron Metabolism.- Iron and the Reticuloendothelial System.- Iron and the Immune System.- Iron Deficiency.- The Liabilities of Iron Deficiency.- The Anemia of Inflammation and Chronic Disease.- Disorders of Red Cell Production and the Iron-Loading Anemias.- The Pathology of Hepatic Iron Overload.- Hepatic Pathobiology of Iron Overload.- HFE-Associated Hereditary Hemochromatosis.- Non-HFE Hemochromatosis.- Miscellaneous Iron-Related Disorders.- Iron and Liver Disease.- Neuropathology and Iron: Central Nervous System Iron Homeostasis.- Iron Metabolism in Cancer and Infection.- Estimation of Body Iron Stores.- Genetic Testing for Disorders of Iron Homeostasis.- The Properties of Therapeutically Useful Iron Chelators.- Clinical Use of Iron Chelators.- Mammalian Models of Iron Homeostasis.- Yeast Iron Metabolism.- Zebrafish Models of Heme Synthesis and Iron Metabolism.
