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Full Description
This volume addresses the structural and functional roles of the cytoskeleton and its dysfunctions which often lead to disease. It provides thorough discussion of microtubules, microfilaments, intermediate filaments, and cytoskeletal functions and dysfunctions in different organ systems. Comprehensive yet concise. The Cytoskeleton In Health And Disease presents cutting-edge discoveries balanced with background information and highlights the new aspects of the research and its impact on the design of new strategies or the identification of new targets for therapeutic intervention.
There is a significant need for a book on this topic, as interest in the cytoskeleton continues to grow as causes and cures for cytoskeletal diseases are further explored in biomedical research. This book is essential reading for scientists, students, and teachers interested in expanding their knowledge related to the cytoskeleton. New researchers entering the field will find classic and well as contemporary information not easily found in the current literature or internet resources.
Contents
Part 1. Overview of the Cytoskeleton.- Brief Overview of the Cytoskeleton.- Part 2. Focus on Cytoskeletal Interactions.- Cytoskeleton Dynamics in Health and Disease: Role of Molecular Switches and Rheostats.- Regulation of Cytoskeleton by the Rho Family of GTPases in Hematopoietic Stem Cells in Health and Disease.- The Role of the Cytoskeleton in Cell Migration, Its Influence on Stem Cells and the Special Role of GFAP in Glial Functions.- Centrosome-Microtubule Interactions in Health, Disease, and Disorders.- Cytoskeletal Elements and Reproductive Success in Animals.- Part 3. Focus on Microtubules.- Cytoskeleton and Regulation of Mitochondrial Translocation in Mammalian Eggs .- Tubulin Detyrosination in Epithelial Cells.- Mutations in Adenomatous Polyposis Coli, Their Role in Cytoskeletal Dynamics and Cancer Onset.- Small GTPases Act as Cellular Switches in the Context of Cilia.- Part 4. Focus on Intermediate Filaments.- Desmin Plays Dual Structural and Regulatory Functions Through Its Interaction with Partners in Muscle.- Desmin Filaments and Desmin-Related Myopathy.- Possible Functions of Intermediate Filaments in Mammalian Ovarian Follicles and Oocytes.- Part 5. Focus on Microfilaments.- Actin Organizing Proteins in Regulation of Osteoclast Function.- The Role of Drebrin-Binding Stable Actin Filaments in Dendritic Spine Morphogenesis.- The Role of the Actin Cytoskeleton in Cancer and Its Potential Use as a Therapeutic Target.
