Full Description
This textbook is written at the dawn of a new era in the management of sepsis. Recent achievements in the clinical management of septic shock are the culmination of decades of basic and applied research by innovative researchers and clinical investigators worldwide. The contributing authors to this book have spearheaded much of this research and the Editors have endeavored to create a textbook that is comprehensive in nature while maintaining a specific focus upon the multitude of work that constitutes the spectrum of sepsis research including: pathophysiology; monitoring systems; general support; microbial aspects; complications; and anti-sepsis therapies.
Contents
Contributors. Introduction; J.L. Vincent, et al. Generalities. 1. Sepsis: The magnitude of the problem; J.L. Vincent. 2. Diagnosis and source of sepsis: The utility of clinical findings; K. Cruz, R.P. Dellinger. 3. Organ failure; R. Moreno, et al. 4. Markers of sepsis; H. Redl, et al. 5. Genetic predisposition; F. Stüber. 6. Quantifying risk in sepsis: A review of illness severity and organ dysfunction scoring; R.S. Wax, et al. Pathophysiology. 7. The pathogenesis of Gram-negative sepsis; C. Papasian, D.C. Morrison. 8. The pathophysiology of Gram-positive shock; R.K. Beaton, J. Cohen. 9. Immunopathogenesis of Gram-negative shock; S.M. Opal, C.E. Huber. 10. Involvement of pro- and anti-inflammatory cytokines in sepsis; J.M. Cavaillon, M. Adib-Conquy. 11. Pathophysiology of immunodepression in ICU patients; H.D. Volk, et al. 12. Pathophysiology of sepsis: the role of nitric oxide; S.J. Finney, T.W. Evans. 13. Apoptosis and the resolution of inflammation in sepsis; G.J. Bellingan. 14. Microvascular alterations in sepsis; A.W. Sielenkämper, et al. 15. Cytopathic hypoxia; M.P. Fink. Monitoring Systems. 16. Invasive hemodynamic monitoring; E. Huettemann, et al. 17. Value of SvO2 in sepsis; T. Boulain, J.L. Teboul. 18. Blood lactate concentrations in sepsis; J.A. Kruse. 19. Veno-arterial PCO2 gradient; V. Castelain, J.L. Teboul. 20. Gas tonometry; E. Silva,L.F. Poli de Figueiredo. General Support. 21. General hemodynamic support; S.M. Hollenberg. 22. Fluid administration; A.R. Webb. 23. Blood transfusion and sepsis; D. Neilipovitz, P.C. Hébert. 24. Catecholamine therapy; C. Martin, et al. 25. Regional effects of catecholamines; A. Meier-Hellmann. 26. Management of respiratory dysfunction in patients with severe sepsis; G.S. Martin, G.R. Bernard. 27. The role of nutritional support in sepsis; D.K. Heyland, et al. Microbial Aspects. 28. The sources of sepsis; C. Alberti, C. Brun-Buisson. 29. Catheter-related sepsis; J.F. Timsit. 30. Control of the source of sepsis; J.C. Marshall. 31. Empirical antibiotic therapy for patients with severe sepsis and septic shock; P.Y. Bochud, et al. 32. Candida infections in the intensive care unit; J.S. Solomkin, et al. 33. Why, when and how to isolate ICU patients; B. Rubinovitch, et al. Complications. 34. The lung in sepsis; P.M. Suter. 35. The heart in sepsis; B. Tavernier, A. Mebazaa. 36. The brain in sepsis; B. Philips, D. Bennett. 37. The gut in sepsis; B. Vallet. 38. The kidney in sepsis; M.G. Vervloet, et al. 39. The coagulation system in sepsis; C.E. Hack. Anti-Sepsis Therapies. 40. Should fever be treated in sepsis? B.A. Cunha. 41. Anti-cytokine therapy; E. Abraham. 42. Heat shock proteins and sepsis: A hot story;
