基本説明
A User friendly approach and layout focuses on diagnosis and management.
Full Description
This unique new book uses a series of focussed questions, comprehensive literature evaluations and structured grades of recommendation to provide evidence for the treatment of hematological disorders, both malignant and benign. With contributions from leading international experts who have a real understanding of evidence-based medicine the book provides comprehensive reviews accompanied by clinical commentaries and recommendations on the best treatment regimes to adopt for individual patients.
The book is split into two sections: the first examines the methodology underlying evidence based practice, and the second concentrates on the clinical practice of hematology, providing current "best evidence" to guide practice in a series of well-defined clinical situations.
This clinical reference is an invaluable source of evidence-based information distilled into guidance for clinical practice which will be welcomed by practitioners, trainees and associated health professionals.
Contents
List of Contributors vii
Preface xi
Part 1 A Guide to the Evidence
Editor: Holger J. Schünemann
1 Rating the Quality of Evidence and Making Recommendations: A Guide to the Spectrum of Clinical Research 3
Holger J. Schünemann, Martin Stanulla, Jan L. Brozek, Gordon G. Guyatt
2 An Overview of Systematic Reviews 10
Martin Prins, Arina ten Cate-Hoek, Pieter Leffers
3 Interpreting Results in Clinical Research: Overview of measures of effect, measures of precision, and measures of diagnostic accuracy for clinicians and researchers 15
Marcello Di Nisio, Harry R. Büller, Patrick M. M. Bossuyt
4 Finding the Evidence in Hematology 23
K. Ann McKibbon, Cynthia J. Walker-Dilks, R. Brian Haynes
5 Applying EBM in Clinical Practice 32
Alessandro Squizzato, Walter Ageno, Davide Imberti
6 Using Evidence to Guide the Diagnosis of Disease 37
Lucas M. Bachmann, Holger J. Schünemann
Part 2 Hemostasis and Thrombosis
Editor: Jeff Ginsberg
7 Diagnosis of Deep Vein Thrombosis 49
Lori-Ann Linkins
8 The Diagnosis of Acute Pulmonary Embolism 56
Victor F. Tapson
9 Initial Therapy of Deep Vein Thrombosis and Pulmonary Embolism 65
Sam Schulman
10 Long-Term Anticoagulation in Venous Thromboembolism 73
Clive Kearon
11 Thrombolytic Therapy for Deep Vein Thrombosis and Pulmonary Embolism 88
Simon J. McRae, John W. Eikelboom
12 Inferior Vena Cava Interruption 99
Michael B. Streiff, Christine L. Hann
13 Management of Venous Thromboembolism in Pregnancy 110
Wee-Shian Chan
14 Pediatric Thrombosis 120
Anthony K. C. Chan, Paul Monagle
15 Bridging Anticoagulation in Patients Who Require Temporary Interruption of Warfarin for Surgery 124
James D. Douketis, Scott Kaatz
16 Evidence-based Approach to the Diagnosis and Management of Thrombotic Thrombocytopenic Purpura 131
Brian Boulmay, Craig S. Kitchens
17 Diagnosis and Management of Disseminated Intravascular Coagulation 138
Julia A. M. Anderson
18 Diagnosis and Management of Hereditary Bleeding Disorders: Including Congenital/Acquired Platelet Function Disorders 145
Nigel S. Key, Alice D. Ma
19 Diagnosis and Management of Acquired Bleeding Disorders: Vitamin K Antagonists 152
Miguel A. Escobar
20 Diagnosis and Management of Heparin-Induced Thrombocytopenia 158
Theodore E. Warkentin, Andreas Greinacher
21 Management of Antiphospholipid Antibody Syndrome 168
Wendy Lim, Mark A. Crowther
Part 3 Benign Hematologic Disorders
Editor: Richard Lottenberg
22 Clinical Questions in Iron Overload 179
Antonello Pietrangelo, Nicola Magrini
23 Aplastic Anemia, Paroxysmal Nocturnal Hemoglobinuria, and Pure Red Cell Aplasia 189
Shivani Srivastava, Richard W. Childs
24 Acquired Anemias: Iron Deficiency, Cobalamin Deficiency, and Autoimmune Hemolytic Anemia 197
Marc S. Zumberg, Marc J. Kahn
25 Immune Thrombocytopenic Purpura 206
James N. George, Sara K. Vesely, George R. Buchanan
26 Neutropenia 215
David C. Dale
27 Hypereosinophilia: Primary and Secondary 221
Florence Roufosse, Michel Goldman, Elie Cogan
28 Porphyrias 229
Gagan Sood, Karl E. Anderson
29 Membrane and Enzyme Abnormalities of the Erythrocyte 238
Patrick G. Gallagher, Ernest Beutler
30 Sickle Cell Disease 244
Richard Lottenberg, Sally C. Davies
31 Evidence-based Treatment of Thalassemia Major 251
Issac Odame, Deborah Rund
Part 4 Malignant Hematologic Disorders
Editor: Ralph M. Meyer
32 Acute Lymphoblastic Leukemia in Adults 263
Stephen Couban, Andrea Kew
33 Acute Myeloid Leukemia in Adults: Remission Induction Therapy 268
Cara A. Rosenbaum, Richard A. Larson
34 Acute Myeloid Leukemia in Adults: Postremission Therapy 278
Cara A. Rosenbaum, Richard A. Larson
35 Current Areas of Controversy in the Treatment of Patients With Newly Diagnosed Acute Promyelocytic Leukemia 287
Martin S. Tallman, Syed A. Abutalib
36 Chronic Lymphocytic Leukemia 294
Bruce D. Cheson
37 Chronic Myeloid Leukemia 300
Irwin Walker
38 Selected Management of Patients with Myelodysplastic Syndromes 305
John M. Storring, Karen W. L. Yee
39 Evidence-based Treatment of Burkitt Lymphoma in Adults 311
John Gerecitano, David J. Straus
40 Primary Central Nervous System Lymphoma 317
Tamara Shenkier
41 Diffuse Large B-cell Lymphoma 327
Michael Crump
42 Follicular Lymphoma 334
Kevin Imrie, Matthew Cheung
43 Lymphoblastic Lymphoma 342
Tyler Y. Kang, John W. Sweetenham
44 Mantle Cell Lymphoma 347
C. Tom Kouroukis
45 Management of Patients with Peripheral T-cell Lymphoma 352
Kerry J. Savage
46 Selected Management Issues of Patients with Hodgkin Lymphoma 365
Ralph M. Meyer
47 Lymphocyte Predominant Hodgkin Lymphoma 372
Brandon McMahon, Jonathan W. Friedberg
48 Management of Patients with Essential Thrombocythemia 378
Guido Finazzi, Giovanni Barosi, Tiziano Barbui
49 Management of Patients with Polycythemia Vera 385
Guido Finazzi, Roberto Marchioli, Tiziano Barbui
50 Evidence-based Review of Therapies in Multiple Myeloma 390
Michael Sebag, A. Keith Stewart
51 Management of Waldenstrom's Macroglobulinemia 396
Christine I. Chen
52 The Role of Hematopoietic Growth Factors in Managing Patients with Hematologic Malignancies 402
Heloisa P. Soares, Ambuj Kumar, Charles Bennett, Benjamin Djulbegovic
Index 413
