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Full Description
DNA Nanoscience: From Prebiotic Origins to Emerging Nanotechnology melds two tales of DNA. One is a look at the first 35 years of DNA nanotechnology to better appreciate what lies ahead in this emerging field. The other story looks back 4 billion years to the possible origins of DNA which are shrouded in mystery. The book is divided into three parts comprised of 15 chapters and two Brief Interludes.
Part I includes subjects underpinning the book such as a primer on DNA, the broader discipline of nanoscience, and experimental tools used by the principals in the narrative. Part II examines the field of structural DNA nanotechnology, founded by biochemist/crystallographer Nadrian Seeman, that uses DNA as a construction material for nanoscale structures and devices, rather than as a genetic material. Part III looks at the work of physicists Noel Clark and Tommaso Bellini who found that short DNA (nanoDNA) forms liquid crystals that act as a structural gatekeeper, orchestrating a series of self-assembly processes using nanoDNA. This led to an explanation of the polymeric structure of DNA and of how life may have emerged from the prebiotic clutter.
Contents
A Note to the Reader Preface Author Biography Acknowledgments INTRODUCTION: Grandma Needs a Walker PART I — The Story Line and Its Underpinnings
CHAPTER ONE — Down the Road and the Gemisch Dramatis Personae, Part I: Nadrian Seeman Molecular Crystals—Inspiration from Escher Perspiration and Reinvention Dramatis Personae, Part II: Noel Clark, Tommaso Bellini Liquid Crystals and Self-Assembly Seeman, Bellini and Clark, and Base Complementarity Conventional Wisdom and an Alternative View Endnotes CHAPTER TWO — DNA: The Molecule That Makes Life Work—and More Erwin Chargaff Rosalind Franklin James Watson, Francis Crick, and Maurice Wilkins DNA Sequencing Polyacrylamide Gel Electrophoresis (PAGE) DNA Synthesis Exercises for Chapter Two Endnotes CHAPTER THREE — Travels to the Nanoworld The Scanning Tunneling Microscope (STM) Moving Atoms With an STM Standing Waves Quantum Corrals Nanomethodology Spherical Nucleic Acids (SNAs) Biodiagnostic Detection Using SNAs Exercises for Chapter Three Endnotes CHAPTER FOUR—Liquid Crystals: Nature's Delicate Phase of Matter Phase Transitions Classes of Liquid Crystals Cell Membranes and the Langmuir Trough Micelles Liquid Crystal Displays Exercises for Chapter Four Endnotes CHAPTER FIVE — Tools of the Trade Polarized Light Microscopy Liquid Crystal Texture Seen Through a Depolarized Light Microscope Transmission Electron Microscopy (TEM) Atomic Force Microscopy (AFM) X-Ray Diffraction and Bragg's Law The Phase Problem Synchrotron X-Ray Diffraction Exercises for Chapter Five Endnotes PART II — The Emerging Technology: Nanomaterials Constructed From DNA CHAPTER SIX — The Three Pillars of Structural DNA Nanotechnology Branched DNA and DNA Junctions Sticky Ends Immobile Four-Arm DNA Junction Two-Dimensional Ligation o
