Full Description
This book comprehensively explores the latest advancements in multi-omics strategies for diagnosing gallbladder cancer. The initial section delves into the genetic mutations and molecular pathways critical for the onset and progression of gallbladder cancer. Through targeted gene sequencing and genomic profiling, it identifies both somatic and rare germline mutations, pinpointing driver genes and predisposing mutations. The subsequent section examines the proteins and molecular pathways altered in gallbladder cancer. It uncovers dysregulated proteins, identifies tumor biomarkers, and evaluates circulating markers for early detection. The book further investigates the impact of infections like Salmonella enterica of the serotypes Paratyphi A on gallbladder tissue, revealing genotoxic effects and potential biomarkers. It also explores the correlation between the gallbladder microbiome, physiological state, and biliary metabolic profile. Towards the end, the book introduces cutting-edge techniques like machine learning-based CT imaging for survival prediction and examines the role of epigenetic pathways and non-coding RNAs in gallbladder cancer. This section also discusses the potential of targeting mTOR pathways and the significance of inflammatory and immune markers, offering a glimpse into the future of gallbladder cancer diagnosis and treatment. This book is a valuable resource for oncologists and researchers working in the fields of oncology, genomics, proteomics, metabolomics, bioinformatics, molecular biology, and translational medicine.
Contents
Chapter 1: Gallbladder Carcinoma: Estimation of Risk Factors and Identification of Prognostic FeaturesChapter 2: Molecular Genetics of Gallbladder Cancer Chapter 3: The Genetic Blueprint of Gallbladder Carcinogenesis: Advances and Discoveries Chapter 4: Genomic Insights in Gallbladder Cancer: Molecular Alterations and Single Polymorphism nucleotides associated with ancestry Chapter 5: Molecular Genetics Alteration and its Prognostic Significance in Gallbladder CarcinogenesisChapter 6: Role of Metabolomics in Carcinoma Gallbladder Chapter 7: Metabolomics Approach to Understanding Gallbladder Cancer Progression Due to Gallstone Disease Chapter 8: Metabolomics: A Potential Biomarkers in Gallbladder CarcinogenesisChapter 9: Long noncoding RNAs (lncRNAs)Chapter 10: Metabolic Reprogramming in Gallbladder CancerChapter 11: Insights and Innovations in Gallbladder Carcinogenesis Chapter 12: Leveraging Artificial Intelligence and Multi-Omics in Gallbladder Cancer Diagnosis and Management Chapter 13: Proteomic Insights in Gallbladder Cancer: Techniques for Biomarker IdentificationChapter 14: Molecular Profile of Gallbladder Cancer
