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Full Description
Zebrafish are becoming a fascinating new animal model for a variety of neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, multiple sclerosis and other demyelinating diseases. Zebrafish produce a lot of embryos, grow quickly, are optically clear, and are receptive to genetic modification. They are therefore superior to current in vivo models in that they may be used to study neurological illnesses and create high-throughput drug screens. This book presents information on the use of zebrafish as a model organism in the modeling of neurodegenerative diseases with contributions from experts in the field. The general characteristics of zebrafish as a model organism are reviewed and neurogenesis and its regulation in zebrafish embryos is explained. Information about the use of zebrafish in NGS diseases such as Parkinson's, Alzheimer's and multiple sclerosis is presented. It is aimed to explain both toxin-induced and genetic models of separately.
Contents
Chapter 1: Main Molecular Mechanisms of Neurodegenerative Disorders. Chapter 2: Molecular Markers of Neurodegenerative Disorders. Chapter 3: Pharmacotherapy of Neurodegenerative Diseases. Chapter 4: Zebrafish Model of Neurodegenerative Disorders. Chapter 5: Zebrafish as a Model Organism for the Investigation of Neurodegenerative Aspects of Autism Spectrum Disorders. Chapter 6: Neurogenesis in the Zebrafish Olfactory Epithelium in Response to Nuerotoxicity and Injury. Chapter 7: Epigenetic Regulations during Neurogenesis in Zebrafish. Chapter 8: Proteomic Approaches on Neurodegenerative Disease Models in Zebrafish. Chapter 9: Zebrafish as a Model for Functional Analyses of Alzheimer's Disease-Related Genes and Drug Development. Chapter 10: Perfluorinated Chemicals, Zebrafish, and Neurodegenerative Disorders.Chapter 11: Effect of Myelination of Neurodegeneration and Neurodegenerative Diseases in the Zebrafish Model.Chapter 12: Zebrafish as a Model Organism to Evaluate the Neurotoxic Effects of Endocrine Disruptive Chemicals. Chapter 13: Using Zebrafish to Explore the Brain-Gut Axis in Neurodegenerative Disorders. Chapter 14: Glyphosate Exposure and Neurological Outcomes in Zebrafish. Chapter 15: Zebrafish Model Organism to Investigate Pain in Neurodegenerative Diseases. Chapter 16: Neurodegenerative Disease Modelling with CRISPR/CAS Systems in Zebrafish. Chapter 17: Zebrafish Genetic Models of Alzheimer's Disease.
Chapter 18: Neurodegenerative Effects of Boron and Other Elements on Zebrafish and Zebrafish Embryos. Chapter 19: Effects of Microplastics and Nano-plastics on Neurodevelopment and Neurodegeneration in Zebrafish. Chapter 20: Investigation of the Effects of Vitamins on Neurodegenerative Diseases using Zebrafish as a Model Organism.Chapter 21: Usability of Zebrafish as a Model Organism to Investigate the Relationship between Breast Milk and Neurodegeneration. Chapter 22: Antimicrobial Agents in Mouthwashes: Unveiling Neurotoxic and Neurodegenerative Impacts through Zebrafish Models.
