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Full Description
The book will cover all the relevant theranostics aspects involving pairs of radiopharmaceuticals used in imaging and therapy for cancer treatment: historical
perspective; cancer biology and radiation biology models; clinical applications; radionuclide production and radiopharmaceutical preparation; source calibration and imaging instrumentation; biokinetic modelling and dosimetric formalisms; epidemiological studies and clinical trials; radiation safety considerations; regulatory requirements; staff education, training and competences; economic projections, and future outlook. It is planned to keep the chapters at a medium academic level. At this time, radiotheranostics information is dispersed in books, journals, congress proceedings and organizations' websites. Compiling and organizing the material should give medical and health physicists not just the necessary tools to estimate and document the individual dosimetry of patients undergoing radiotheranostics treatment, but will also empower them to
• convince the cancer community that such a dosimetry improves cancer control and results
in longer survival times and
• influence national policy makers to require organ dose estimates/calculations.
The book is aimed at academic and practicing clinical medical and health physicists with
basic knowledge of nuclear medicine. Although the book is not meant as a textbook, medical
physicists in nuclear medicine physics training may also find the book useful.
Contents
List of Common Acronyms
Part 1 - Introduction
Chapter 1. Radiotheranostics: Challenges Today
Part 2 - Radiochemistry and Radiobiology
Chapter 2. Radiopharmaceutical Preparations and Radiolabeling Strategies
Chapter 3. New Insights Into the Radiation Biology of Radiotheranostics
Chapter 4. Radiation Embryology: Human and Animal Studies
Part 3 - Particle Dosimetry
Chapter 5. Alpha- and Beta-particle Therapy and Dosimetry
Chapter 6. Auger Emitters
Chapter 7. Positrons: Their Potential Role in Radionuclide Therapy
Part 4 - Dosimetry Formalisms
Chapter 8. Biokinetic Modelling For Radionuclide Dosimetry
Chapter 9. Standardized Tumor and Organ Dosimetry
Chapter 10. Image-based Dosimetry Procedures
Chapter 11. Combining External Beam Radiotherapy and Radionuclide Therapy
Chapter 12. Uncertainties in Dose Calculations
Part 5 - Safety
Chapter 13. Design, Shielding, and Operational Radiation Safety Aspects of the Radiotheranostic Facility
Chapter 14. Management of Deceased Patients Under Treatment (Radioactive Cadavers)
Chapter 15. Radiopharmaceutical Regulatory Requirements
Part 6 - Future Directions and Opportunities
Chapter 16. The Economics of Theranostics
Chapter 17. Artificial intelligence in Radiotheranostics