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Full Description
Radiotheranostics - A Primer for Medical Physicists II: Radiochemistry, Radiobiology, Dosimetry, Safety, Economics, and AI expands upon the radiotheranostic topics in cancer care covered in Volume I, which includes cancer biology, clinical applications, radionuclide production, source calibration, imaging instrumentation, and staff education, training, and competencies. Building on these foundational elements, Volume II offers an in-depth coverage of radiopharmaceutical preparation and radiolabeling strategies. It presents new insights into radiation biology, including studies on human and animal radiation embryology. The dosimetry section addresses alpha-, beta-, and Auger-emitting radionuclides and explores the therapeutic potential of positrons. It emphasizes biokinetic modeling, standardized and image-based dosimetry procedures, and the quantification of uncertainties in dose calculations. Essential safety topics are also thoroughly examined, including radiation shielding, facility design, the management of deceased radiotheranostic patients, and current regulatory requirements. The volume concludes with forward-looking chapters on the economics of theranostics and the transformative role of artificial intelligence in enhancing precision medicine.
The chapters are designed to equip medical physicists with the tools necessary to accurately estimate and document individual patient dosimetry and demonstrate the clinical value of dose calculations in improving cancer outcomes and survival rates.
The book is intended for academic and practicing clinical medical and health physicists with a basic knowledge of nuclear medicine. Although not structured as a textbook, medical physicists in nuclear medicine physics training will also find the book helpful.
Key Features:
Covers everything medical and health physicists need to know in one book
The text is rigorous yet easily understandable to physics majors
References are extensive so that readers can delve deeper into the subject
Contents
List of Common Acronyms
Part 1 - Introduction
Chapter 1. Radiotheranostics: Challenges Today
Part 2 - Radiochemistry and Radiobiology
Chapter 2. Radiopharmaceutical Preparations and Radiolabeling Strategies
Chapter 3. New Insights Into the Radiation Biology of Radiotheranostics
Chapter 4. Radiation Embryology: Human and Animal Studies
Part 3 - Particle Dosimetry
Chapter 5. Alpha- and Beta-particle Therapy and Dosimetry
Chapter 6. Auger Emitters
Chapter 7. Positrons: Their Potential Role in Radionuclide Therapy
Part 4 - Dosimetry Formalisms
Chapter 8. Biokinetic Modelling For Radionuclide Dosimetry
Chapter 9. Standardized Tumor and Organ Dosimetry
Chapter 10. Image-based Dosimetry Procedures
Chapter 11. Combining External Beam Radiotherapy and Radionuclide Therapy
Chapter 12. Uncertainties in Dose Calculations
Part 5 - Safety
Chapter 13. Design, Shielding, and Operational Radiation Safety Aspects of the Radiotheranostic Facility
Chapter 14. Management of Deceased Patients Under Treatment (Radioactive Cadavers)
Chapter 15. Radiopharmaceutical Regulatory Requirements
Part 6 - Future Directions and Opportunities
Chapter 16. The Economics of Theranostics
Chapter 17. Artificial intelligence in Radiotheranostics
