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Full Description
Recent years have seen an explosion of activity in the field of biomedical imaging in an attempt to understand the behavior of the brain in healthy and disease states. With the emergence of genetically manipulated laboratory mice and the knowledge of the mouse genome, we are entering an exciting new era with revolutionary tools for experimental research. Noninvasive imaging techniques capable of providing both anatomical and functional descriptions of the brain have become essential. Among the various imaging methodologies, magnetic resonance imaging (MRI) stands in the forefront by virtue of its contrast versatility and pathophysiological specificity.
Emphasizing the relationship between physiological microenvironment and macroscopic imaging signal changes, Biomedical Imaging in Experimental Neuroscience presents a comprehensive review of the noninvasive biomedical imaging techniques available for laboratory animal research. Focusing on MRI, but recognizing the multiple forms of imaging information, this book outlines the scope and limitations of these methods and analyzes their impact on in vivo neuroscience research. The book is intended for the biologist who may not have a background in the physical sciences. This applied guide also provides a concise theoretical description of the pertinent physics.
Noninvasive imaging offers the obvious benefits of reducing sample sizes and identifying new and unanticipated behaviors. Biomedical Imaging in Experimental Neuroscience presents detailed information for biologists interested in how biomedical imaging may augment their in vivo research and for clinical practitioners seeking deeper insights into the association between imaging findings and disease pathophysiology.
Contents
Introduction. Principles of MRI and the Generation of Contrast. MRI Measurement of Cerebral Perfusion and Application to Experimental Neuroscience. MRI Measurement of Cerebral Water Diffusion. Diffusion Weighted MRI in Experimental Research. Functional Magnetic Resonance Imaging. Functional Imaging in the Non-Human Primate, Elizabeth Disbrow. Pharmacological Magnetic Resonance Imaging (phMRI). Anatomical Studies in the Rodent Brain and Spinal Cord: Applications of Magnetic Resonance Microscopy. Magnetic Resonance Spectroscopy: Principles and Applications. Molecular Imaging with Novel MRI Contrast Agents. Small Animal Imaging with Positron Emission Tomography. The Future for Biomedical Imaging in Experimental Research: Emerging and Alternative Technologies.
