基本説明
薬物動態学と薬力学の臨床的側面の世界的な第一人者二名によって執筆された、この分野の権威あるテキストの改訂版。旧版タイトル"Clinical Pharmacokinetics : Concepts and Applications".
Previous ed.: 1995.
Full Description
Formerly Clinical Pharmacokineticsupdated Fourth Edition has been retitled Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications to reflect the increasing body of knowledge linking the two concepts that explain the relationship between drug administration and drug response. This revised edition also reflects the explosion in our understanding at the molecular and mechanistic levels of all the processes controlling the pharmacokinetics of drugs. The text is authored by two leading international experts on the clinical aspects of pharmacokinetics/pharmacodynamics and is widely considered one of the authoritative texts on the subject.A companion website includes the full text online, plus interactive simulations for student practice using different pharmacokinetic/pharmacodynamic models and parameters.
Contents
PrefaceDefinition of SymbolsNon-Proprietary and Brand Names of Drugs in Text and IllustrationsI. Basic Considerations1. Therapeutic Relevance2. Fundamental Concepts and TerminologyII. Exposure and Response after a Single Dose3. Kinetics Following an Intravenous Bolus Dose4. Membranes and Distribution5. Elimination6. Kinetics Following an Extravascular Dose7. Absorption8. Response Following a Single DoseIII. Therapeutic Regimens9. Therapeutic Window10. Constant-Rate Input11. Multiple Dose RegimensIV. Individualization12.Variability13.Genetics14. Age, Weight, and Gender15. Disease16. Nonlinearities17. Drug Interactions18. Initiating and Managing TherapyV. Supplemental Topics19. Distribution Kinetics20. Metabolites and Drug Response21. New! Protein Drugs22. New! Prediction and Refinement of Human Kinetics from In Vitro, Preclinical, and Early Clinical DataAppendicesA. Assessment of AUCB. Ionization and the pH Partition HypothesisC. Distribution of Drugs Extensively Bound to Plasma ProteinsD. Plasma-to-Blood Concentration RatioE. Well-stirred Model of Hepatic ClearanceF. Absorption KineticsG. Wagner-Nelson MethodH. Mean Residence TimeI. Amount of Drug in Body on Accumulation to PlateauJ. Answers to Study Problems
