Epilepsy : Models, Mechanisms, and Concepts

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Epilepsy : Models, Mechanisms, and Concepts

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  • 製本 Hardcover:ハードカバー版/ページ数 544 p.
  • 言語 ENG,ENG
  • 商品コード 9780521392983
  • DDC分類 616.85307


New in paperback. Hardcover was published in 1993. Concentrates on the concepts and models of epilepsy that have been developed as a result of this research. Written by prominent researchers in the field, it describes and discusses the relevant models used to address critical questions, and reviews the most up-to-date issues.

Full Description

Advances in epilepsy research are occurring at a rapid rate, resulting in a bewildering wealth of data. The implications of this knowledge for future research and clinical practice can be confusing. This volume concentrates on the concepts and models of epilepsy which have been developed as a result of this research. Written by prominent researchers in the field, this book presents a number of major concepts and hypotheses through which epilepsy research has been advanced. Chapters focus on the pathways and mechanisms through which seizure activity is initiated and spread, in both normal and abnormal brain tissues, and discuss the special properties of epileptogenesis in the immature brain. In a field in which rapid advances lead to constant update of empirical data, this book takes a conceptual approach to the subject and provides a solid framework within which to understand the emerging issues. It will be relevant to basic neuroscientists, neurologists and neurosurgeons.

Table of Contents

Part I. Chronic Models in Intact Animal -
Concepts and Questions: 1. The kindling model
of epilepsy J. O. McNamara
2. Focal trigger zones and pathways of
propagation in seizure generation K. Gale
3. Genetic models of the epilepsies P. C. Jobe
4. Noradrenergic modulation of excitability:
transplantation approaches to epilepsy research
O. Lindvall
5. Sensitivity of the immature central nervous
system to epileptogenic stimuli S. L. Moshe
Part II. Features of the Epileptogenic Brain:
6. Neurophysiological studies of alteration in
seizure susceptibility during brain development
J. W. Swann
7. Electrophysiology and pharmacology of human
neocortex and hippocampus in vitro M. Avoli
8. Cell death, plasticity and epilepsy:
insights provided by experimental models of
hippocampal sclerosis J. Franck
9. Sprouting as an underlying cause of
hyperexcitability in experimental models and in
the human epileptic temporal lobe T. P. Sutula
10. Rapidly recurring seizures and status
epilepticus: ictal density as a factor in
epileptogenesis E. W. Lothman
Part III. Normal Brain Mechanisms That Support
Epileptiform Activities: 11. Brain slice models
for the study of seizures and interictal spikes
W. A. Wilson and A. Bragdon
12. Generation of epileptiform discharge by
local circuits of neocortex B. W. Connors and
Y. Amitai
13. Study of GABAergic inhibition and GABAA
receptors in experimental epilepsy R. K. S.
Wong and R. Miles
14. High potassium-induced synchronous bursts
and electrographic seizures C. J. McBain
15. Antiepileptic effects of organic calcium
channel blockers in animal experiments E.-J.
Speckmann and J. Walden.