Neuronal Networks of the Hippocampus

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Neuronal Networks of the Hippocampus

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  • 製本 Hardcover:ハードカバー版
  • 言語 ENG
  • 商品コード 9780521364812
  • DDC分類 599.0188

Full Description


The questions of how a large population of neurons in the brain functions, how synchronized firing of neurons is achieved, and what factors regulate how many and which neurons fire under different conditions form the central theme of this book. Using a combined experimental-theoretical approach unique in neuroscience, the authors present important techniques for the physiological reconstruction of a large biological neuronal network. They begin by discussing experimental studies of the CA3 hippocampal region in vitro, focusing on single-cell and synaptic electrophysiology, particularly the effects a single neuron exerts on its neighbours. This is followed by a description of a computer model of the system, first for individual cells then for the entire detailed network, and the model is compared with experiments under a variety of conditions. The results shed significant light into the mechanisms of epilepsy, electroencephalograms, and biological oscillations and provide an excellent test case for theories of neural networks. Researchers in neurophysiology and physiological psychology, physicians concerned with epilepsy and related disorders, and researchers in computational neuroscience will find this book an invaluable resource.

Table of Contents

Acknowledgments
Prologue
1. The hippocampus in context
2. Physiology of single neurons: voltage- and
ligand-gated ionic channels
3. Synaptic function and organization of the
CA3 region
4. The single-cell model
5. Model of the CA3 network
6. Collective behaviours of the CA3 network:
experiment and model
7. Collective behaviours of the CA3 network:
spontaneous oscillations and synchronized
synaptic potentials
8. Field effects
9. Theoretical approaches: mathematical neural
networks
Appendix
Conclusion
Notes
References
Index.