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Full Description
DNA in Health, Identity and Ancestry examines the human genome and advances in molecular techniques in relation to their value in health, genetic ancestry, and forensic DNA. This book systematically presents these three areas, providing new insights into recent developments in these fields, including gene editing, ancestral fraction determination, and DNA profiling. It covers the latest advances in molecular biology to understand the pertinent issues in these areas. DNA in Health, Identity and Ancestry provides an introduction to human genomes, and then delves into health, forensics and ancestry across 36 chapters. Each section is concluded with practical case studies to demonstrate the application of the principles discussed in each respective section. This book is a valuable resource for researchers, practitioners, and postgraduate students in biochemistry, molecular biology and genetics. It not only provides them with fundamental knowledge on genetics, diseases, population genetics and forensic DNA, but also presents advances, technical operational standards, analytical tools and recent developments in these respective areas.
Contents
1. Introduction to human genomes: nuclear and mitochondrial DNA
2. Genetic Testing: A Biomedical, Social and Ethical Framework
3. CRISPR/Cas9: The Future of Human Gene Editing
4. Pharmacogenomics
5. Infectious disease diagnosis via DNA analysis
6. Donor and recipient matching for transfusion and transplantation surgery
7. Circulating free DNA: history, applications, and promises
8. Metagenomics of environmental samples
9. DNA extraction methods for pathogen analysis
10. Characterization and application of environmental DNA in multi-species biofilms
11. TLE variants and immune thrombocytopenia susceptibility
12. X-chromosome: Genetics, function and health.
13. Food intolerance and coeliac disease in past human populations through DNA analysis
14. Puzzling ABO Discrepancy Case Resolved Through Molecular Technique
15. STR and mitochondrial DNA profiling for casework and paternity cases
16. DNA databanking, hit matches and ethical issues
17. Forensic parameters in Kedayan inferred using mtDNA data
18. The application of dual mitochondrial markers for detecting porcine DNA in gelatine-containing processed food products
19. DNA analysis of Elmina plane crash victims: a case study
20. Archaeogenetics of human history
21. Ancient DNA extraction and amplification techniques
22. The usefulness of Y chromosome in the study of past populations
23. Human migrations and settlements in Malay Archipelago
24. Blood groups, HPA, HNA, cytokines and HLA-G: genetics and ancestry
25. Ethnic-specific patterns of GSTM1 and GSTT1 in Malays, Chinese and Indians with specific comparison to Europeans
26. The Archaeological Heritage of the Niah National Park's Caves Complex: History, Current Status, and Future Prospects
27. The medical significance of human population genetics in southeast Asia and Oceania
28. Genomic ancestry and health from mtDNA perspectives
