Full Description
ABO-incompatible and positive crossmatch procedures now permit thousands of formerly ineligible patients to be candidates for organ transplant. The protocols and procedures for kidney, heart, lung, pancreas and liver transplants using these new approaches are described in this landmark book. "Incompatible Solid Organ Transplantation: Crossing ABO-Incompatible and Positive Crossmatch Barriers" is the first comprehensive resource documenting these exciting procedures and includes contributions from leading transplant centers around the world. Topics covered include both ABO-incompatible solid organ transplantation and positive crossmatch; immunobiology; antibody detection, monitoring and removal; antibody mediated rejection; desensitization protocols and operative techniques; an overview of the Johns Hopkins Comprehensive Transplant Center program; paired kidney exchange; and future directions.
Contents
History of incompatible organ transplantation .-A mechanistic view of antibody production .-Antibody/endothelial cell interactions .-Accommodation and B-Cell tolerance .-The role of complement in endothelial injury .-Overview of cell-based and solid phase assays .-Monitoring HLA antibodies during desensitization and AMR .-Isoagglutinin titers and scoring .-Piasmapheresis .-Intravenous immunoglobulin .-Immunoadsorption .-Splenectomy and anti-CD20 antibodies .-Histologic and immunohistologic features of AMR .-Treatment of de novo AMR .-Treatment of AMR in the context of desensitization .-ABO incompatible transplantation .-Positive crossmatch transplantation .-Immunosuppression for ABO incompatible transplants .-Preoperative assessment and risk profiling .-Redo-kidney transplantation: surgical challenges .-Postoperative care .-A transplant coordinator's perspective .-A nursing perspective .-Psychosocial challenges .-Infrastructure, financial management, and reimbursement .-Incompatible heart transplantation .-Incompatible lung transplantation .-Incompatible pancreas transplantation .-Incompatible liver transplantation .-Role of non-directed donors .-Live donor paired kidney exhange .-Inderect paired kidney exhange .-Incompatible organ transplantation: future directions and goals
