Full Description
Consult the definitive resource in rheumatology for an in-depth understanding of scientific advances as they apply to clinical practice. Masterfully edited by Drs. Gary S. Firestein, Ralph C. Budd, Sherine E. Gabriel, Iain B. McInnes, and James R. O'Dell, and authored by internationally renowned scientists and clinicians in the field, Kelley and Firestein's Textbook of Rheumatology, 10th Edition, delivers the knowledge you need for accurate diagnoses and effective patient care. From basic science, immunology, anatomy, and physiology to diagnostic tests, procedures, and specific disease processes, this state-of-the-art reference provides a global, authoritative perspective on the manifestations, diagnosis and treatment of rheumatic diseases.An ideal balance of the basic science you need to know and how to apply that information to clinical practice.An integrated chapter format allows you to review basic science advances and their clinical implications in one place and get dependable, evidence-based guidance for the full range of rheumatologic diseases and syndromes.Videos online demonstrate the complete musculoskeletal exam, including abnormal findings and the arthroscopic presentation of diseased joints.New content on the latest diagnostic perspectives and approaches to therapy, including five brand-new chapters: Metabolic Regulation of Immunity, Principles of Signaling, Research Methods in the Rheumatic Diseases, Novel Intracellular Targeting Agents, and IgG4-Related Diseases.New and expanded chapter topics on small molecule treatment, biologics, biomarkers, epigenetics, biosimilars, and cell-based therapies.More schematic diagrams clearly summarize information and facilitate understanding.
Contents
1 Biology of the Normal Joint2 Synovium3 Cartilage and Chondrocytes4 Biology, Physiology, and Morphology of Bone5 Muscle: Anatomy, Physiology, and Biochemistry6 Biomechanics7 Tissue Engineering8 Proteinases and Matrix Degradation9 Dendritic Cells10 MACROPHAGES11 Neutrophils12 T Lymphocytes13 B Cells14 Fibroblasts and Fibroblast-like Synoviocytes15 Mast Cells16 Platelets and Rheumatic Diseases17 Innate Immunity18 ADAPTIVE IMMUNITY and Organization of Lymphoid Tissues19 Autoimmunity21 Genetics of Rheumatic Diseases22 Epigenetics of rheumatic diseases 23 Complement System24 Prostaglandins, Leukotrienes, and Related Compounds25 Cell Recruitment and Angiogenesis26 Cytokines28 Cell Survival and Death in Rheumatic Diseases29 Animal Models of Rheumatic Diseases30 Neural regulation of Pain and Inflammation33 Assessment of Health Outcomes IN RHEUMATIC DISEASES34 Biologic Markers35 Occupational and Recreational MSK Disorders36 Cardiovascular Risk in Rheumatic Disease37 Cancer Risk in Rheumatic Diseases38 Introduction to Physical Medicine, Physical Therapy and Rehabilitation39 Pregnancy and Rheumatic Diseases40 History and Physical Examination of the Musculoskeletal System41 EVALUATION AND DIFFERENTIAL DIAGNOSIS OF Monoarticular Arthritis42 EVALUATION AND DIFFERENTIAL DIAGNOSIS OF Polyarticular Arthritis43 The Skin and Rheumatic Diseases44 The Eye and Rheumatic Diseases45 Neck Pain46 Shoulder Pain47 Low Back Pain48 Hip and Knee Pain49 Ankle and Foot Pain50 Hand and Wrist Pain51 Temporomandibular Joint Pain52 Fibromyalgia53 Synovial Fluid Analysis, Synovial Biopsy, and Synovial Pathology54 Arthrocentesis and Injection of Joints and Soft Tissue55 Antinuclear Antibodies 56 Autoantibodies in rheumatoid arthritis57 Acute Phase Reactants58 Imaging Modalities in Rheumatic Disease59 Prostanoid Biology and its Therapeutic Targeting60 Glucocorticoid Therapy61 Traditional DMARDS: Methotrexate, Leflunomide, Sulfasalazine, and Hydroxychloroquine and Combination Therapies62 TRADITIONAL Immunoregulatory Drugs63 Anticytokine Therapies64 Cell Targeted Biologics65 NOVEL INTRACELLULAR TARGETING AGENTS66 Urate Lowering Therapy67 Analgesic Agents in Rheumatic Diseases68 Nutrition and Rheumatic Disease69 Etiology and Pathogenesis of Rheumatoid Arthritis70 Clinical Features of Rheumatoid Arthriti71 Treatment of Rheumatoid Arthritis72 Early Synovitis and Early Undifferentiated Arthritis73 Sjogren's Syndrome74 Etiology and Pathogenesis of Spondyloarthropathies75 Ankylosing Spondylitis76 Undifferentiated Spondyloarthritis and Reactive Arthritis77 Psoriatic Arthritis78 Enteropathic Arthritis79 Etiology and Pathogenesis of SLE80 Clinical Features of SLE81 Treatment of SLE82 Antiphospholipid Syndrome83 Etiology and Pathogenesis of Scleroderma84 Clinical Features and Treatment of Scleroderma85 Inflammatory Diseases of Muscle and Other Myopathies86 Overlap Syndromes87 Classification and Epidemiology of Systemic Vasculitis88 Giant Cell Arteritis, Polymyalgia Rheumatica, and Takayasu's Arteritis89 Antineutrophil Cytoplasmic Antibody-Associated Vasculitis90 Polyarteritis and Related Disorders91 Immune Complex-Mediated Small Vessel Vasculitis92 Isolated Angiitis of the Nervous System93 Bechet's Disease94 Etiology and Pathogenesis of Gout and Hyperuricemia95 Clinical Features and Treatment of Gout96 Calcium Crystal Diseases: Calcium Pyrophosphate Dihydrate and Basic Calcium Phosphate97 Familial Autoinflammatory Syndromes98 Etiology and Pathogenesis of Osteoarthritis99 Clinical Features of Osteoarthritis100 Treatment of Osteoarthritis101 Metabolic Bone Disease102 Proliferative Bone Disease103 Osteonecrosis104 Relapsing Polychondritis105 Heritable Diseases of Connective Tissue106 Etiology and Pathogenesis of Juvenile Idiopathic Arthritis107 Treatment of Juvenile Inflammatory Arthritis108 SLE, Juvenile Dermatomyositis, Scleroderma and Vasculitis109 Bacterial Arthritis110 Lyme Disease111 Mycobacterial Infections of Bones and Joints112 Fungal Infections of Bones and Joints113 Rheumatic Manifestations of HIV Infection114 Viral Arthritis115 Rheumatic Fever and Post-Streptococcal Arthritis 116 Amyloidosis117 Sarcoidosis118 Hemachromotosis119 Hemophilic Arthropathy120 Rheumatic Manifestations of Hemoglobinopathies121 IgG4-RELATED DISEASES122 Arthritis Accompanying Endocrine and Metabolic Disorders123 Musculoskeletal Syndromes Associated with Malignancy124 Tumors and Tumor-like Lesions of Joints and Related Structures
