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Full Description
The most engaging and accessible account of cancer biology which clearly links our understanding of cancer with the development of new therapeutics.
Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers an accessible, engaging, and optimistic account of cancer biology for undergraduate and graduate students.
Key features
- Describes the theoretical basis of cancer biology and shows how this theory is applied to develop new cancer therapies, giving students a clear appreciation of how theoretical knowledge can be translated into therapeutic strategies
- Draws on the latest research in cancer biology
- Features a variety of learning features to help students engage with the concepts presented: 'Pause and think'; 'How do we know that?'; 'In the clinic'; self-tests; and activities
New to this edition
- New themes that weave throughout the book, such as the two-way interactions between the microenvironment and the tumour, systemic effects of cancer, and the role of plasticity and heterogeneity in cancer evolution
- Expanded coverage of cancer genomics, including single cell genomics and spatial transcriptomics, highlighted in the concluding chapter
- A new feature called 'In the clinic' that highlights current or potential applications of cancer biology to clinical practice
- Updates on newly approved cancer therapeutics
- Includes additional primary data from the literature and key references to provide a resource of up-to-date experimental evidence
- Expanded artwork programme and new 'figure sequences' (in the enhanced e-book) to help readers understand molecular pathways over time
Digital formats and resources
The 6th edition is available for students and institutions to purchase in a variety of formats: the e-book and Science Trove offer a mobile experience and convenient access along with multiple choice questions, audio clips, functionality tools, navigation features and links that offer extra learning support.
For more information about e-books, please visit https://www.oxfordtextbooks.co.uk/ebooks
Contents
1: Introduction
2: The transformable cancer genome: mutations versus repair
3: Regulation of gene expression
4: Growth factor signaling and oncogenes
5: The cell cycle
6: Tumour suppressor genes
7: Apoptosis
8: Cancer stem cells, lineage plasticity and disrupted differentiation: focus on colon cancer and leukemias
9: Metastasis
10: Angiogenesis
11: Reprogrammed metabolism and diet
12: Tumour immunology and immunotherapy
13: Inflammation, infection, and the microbiome
14: Cancer genomics and other methods for research and clinical development
