基本説明
Helps the non-specialist undertake cancer risk assessment in the context of a family history, which also provides the foundation for cancer genetics for the specialist.
Full Description
The need to expand expertise in cancer genetics beyond highly specialized genetics clinics is increasingly being recognized. In response, this practical book provides oncologists, specialist nurses, genetic counsellors, family doctors, and geneticists with comprehensive and easy-to-use guidelines on risk assessment and appropriate management.
The book focuses on common familial cancers such as breast, colorectal, ovary, prostate and melanoma, and separate chapters cover cancer predisposing syndromes such as neurofibromatosis, familial adenomatous polyposis and their management.
Contents
INTRODUCTION ; 1. How to evaluate a family history ; 2. Guidelines for referral in Europe ; 3. Guidelines for genetic counselling, testing and referral in North America ; 4. Principles and applications of gene testing for common cancers ; RISK ASSESSMENT OF COMMON MALIGNANCIES ; 5. Risk estimation in breast cancer ; 6. Risk estimation in colorectal cancer ; 7. Risk estimation in ovarian cancer ; 8a Management of familial breast and ovarian cancer in Europe ; 8b Management of familial breast and ovarian cancer in North America ; 9. Management of familial adenomatous polyposis and other inherited polyposis syndromes ; 10. Management of hereditary non-polyposis colorectal cancer ; 11. Management and risk assessment of less common familial cancers ; INHERITED CANCER SYNDROMES ; 12. The neurofibromatoses ; 13. von Hippel-Lindau disease ; 14. Multiple endocrine neoplasias ; 15. Gorlin Syndrome ; 16. The Li-Frameni Syndrome ; 17. Other tumour predisposing syndromes ; 18. The ethical and insurance issues of cancer genetics
