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Full Description
Ion Channels and Calcium Signaling in the Microcirculation, Volume 85, the latest release in the Current Topics in Membranes series, highlights the latest advances in the expression and function of ion channels and calcium signaling in vascular smooth muscle and endothelial cells in resistance arteries, arterioles and capillaries, critical components of microcirculation, the business end of the cardiovascular system. Leading experts have contributed chapters, including Smooth muscle ion channels and calcium signaling in the regulation of striated muscle arteriolar tone; Endothelial KIR channels as a key component of shear stress-induced mechanotransduction; Endothelial TRPV4 channels and vasodilator reactivity, and much more.
Additional sections cover cerebral capillary endothelial TRPA channels and the regulation of blood flow; Endothelial mineralocorticoid receptors and the regulation of TRPV4 function in cerebral parenchymal arterioles in hypertension; Subcellular calcium signaling and myogenic tone development in the retinal microcirculation; Microvascular KIR channels: Basis, properties and regulation by lipid and hemodynamic forces, Ion channels and calcium signaling in capillary endothelial cells; Ion channels and calcium signaling in bladder arterioles and resistance arteries, and Myoendothelial feedback and endothelial IKCa and sKCa channels.
Contents
1. Introduction to ion channels and calcium signaling in the microcirculation
William F. Jackson
2. Ion channels and the regulation of myogenic tone in peripheral arterioles
William F. Jackson
3. Endothelial inwardly-rectifying K+ channels as a key component of shear stress-induced mechanotransduction
Ibra S. Fancher and Irena Levitan
4. Endothelial TRPV4 channels and vasodilator reactivity
Yen-Lin Chen and Swapnil K. Sonkusare
5. Regulation of vascular tone by transient receptor potential ankyrin 1 channels
Pratish Thakore, Sher Ali and Scott Earley
6. Regulation of ion channels in the microcirculation by mineralocorticoid receptor activation
Laura Chambers and Anne M. Dorrance
7. Ion channels and myogenic activity in retinal arterioles
Peter Barabas, Josy Augustine, José A. Fernández, J. Graham McGeown, Mary K. McGahon and Tim M. Curtis
8. KIR channels in the microvasculature: Regulatory properties and the lipid-hemodynamic environment
Maria Sancho and Donald G. Welsh
9. Ion channels in capillary endothelium
Daniela C. G. Garcia and Thomas A. Longden
10. Excitability and contractility in arterioles and venules from the urinary bladder
Nathan R. Tykocki and Frederick C. Monson
11. Intrinsic regulation of microvascular tone by myoendothelial feedback circuits
Hamish A.L. Lemmey, Christopher J. Garland and Kim A. Dora
