C型肝炎ウイルス:周期・構造・機能・阻害<br>Studies on Hepatitis Viruses : Life Cycle, Structure, Functions, and Inhibition (1ST)

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C型肝炎ウイルス:周期・構造・機能・阻害
Studies on Hepatitis Viruses : Life Cycle, Structure, Functions, and Inhibition (1ST)

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  • 製本 Paperback:紙装版/ペーパーバック版/ページ数 230 p.
  • 言語 ENG
  • 商品コード 9780128133309
  • DDC分類 616

Full Description


Studies on Hepatitis VirusesInhibition presents the latest on this systemic infection that predominantly affects the liver with inflammation that can be acute or chronic. Hepatitis viruses have been the subject of intense study in the last twenty years, with a wealth of information related to their lifecycle, structure, functions and inhibition being presented. This book compiles the most important developments and research, giving users a very useful guide on this evolving area of virology and medicinal chemistry.

Table of Contents

About the Author                                   ix
Preface xi
1 Viral Hepatitis: Historical Perspective, 1 (14)
Etiology, Epidemiology, and Pathophysiology
1 Introduction 1 (1)
2 Etiology of Infection 2 (2)
3 Epidemiology 4 (4)
4 Pathophysiology 8 (2)
5 Conclusions 10 (5)
References 11 (4)
2 Hepatitis Viruses: Structure and 15 (20)
Replication
1 Introduction 15 (4)
2 Structure and Replication of Hepatitis 19 (11)
Viruses
3 Conclusions 30 (5)
References 31 (2)
Further Reading 33 (2)
3 Inhibition of Viruses: Promising Targets 35 (32)
and Their Importance
1 Introduction 35 (1)
2 Polymerases 35 (3)
3 Proteases 38 (4)
4 Important Drug Targets in Hepatitis 42 (14)
Viruses
5 Conclusions 56 (11)
References 57 (8)
Further Reading 65 (2)
4 Hepatitis Therapy: Present Status 67 (12)
1 Introduction 67 (2)
2 Treatment of Hepatitis 69 (1)
3 Hepatitis Therapies 69 (8)
4 Conclusions 77 (2)
References 77 (2)
5 The Medicinal Chemistry of Antihepatitis 79 (18)
Agents I: Anti-HAV, Anti-HDV, and Anti-HEV
Agents
1 Introduction 79 (1)
2 Anti-HAV Drugs Studies 80 (8)
3 Anti-HDV Drugs Studies 88 (3)
4 Anti-HEV Drugs Studies 91 (2)
5 Conclusions 93 (4)
References 94 (2)
Further Reading 96 (1)
6 The Medicinal Chemistry of Antihepatitis 97 (36)
Agents II: Anti-HBV Agents
1 Introduction 97 (1)
2 Experimental Studies 97 (21)
3 Theoretical Studies 118(8)
4 Conclusions 126(7)
References 126(7)
7 The Medicinal Chemistry of Antihepatitis 133(78)
Agents III: Anti-HCV Agents
1 Introduction 133(2)
2 Experimental Studies 135(39)
3 Theoretical Studies 174(25)
4 Conclusions 199(12)
References 200(11)
8 Status and Global Strategy of Prevention 211(6)
of Hepatitis Virus Infection
1 Introduction 211(1)
2 Present Status of Viral Hepatitis 211(2)
3 Global Strategy of Prevention 213(1)
4 Conclusions 214(3)
Source 215(1)
References 215(2)
Index 217