Full Description
Natural Hosts of SIV: Implications in AIDS thoroughly reviews the possible mechanisms by which African nonhuman primate natural hosts of lentiviruses remain essentially disease-free while other hosts exhibit disease and death. The book ultimately indicates directions for further research and potential translations of this compelling phenomenon into novel approaches to treat and prevent HIV. When Asian non-human primate non-natural hosts are experimentally infected with viruses isolated from African species, disease and death normally results. Meanwhile, these African nonhuman primate natural hosts maintain similar levels of plasma and cellular viremia and exhibit compellingly different, essentially disease-free, states. This work attempts to answer the question of how the natural host remains disease resistant.
Contents
1. Overview
Aftab Ansari and Guido Silvestri
2. Historical perspective
Preston Marx
3. SIV infections in the wild
Cristian Apetrei and Martine Peeters
4. Virology of SIVs
Frank Kirchhoff
5. SIV infection of chimpanzees
Jonathan Heeney, Edward James Donald Greenwood and Fabian Schmidt
6. Pathology of acute & chronic infection
Francois Villinger and Sanjeev Gumber
7. Mucosal immunity
Jason Brenchley
8. Innate immunity
Steven E. Bosinger and R. Keith Reeves
9. Humoral immune responses
Cynthia Ann Derdeyn and Reinhard Kurth
10. Cellular immune responses
Amitinder Kaur
11. Chronic immune activation
Donald Sodora
12. Pattern of infected cells
Mirko Paiardini and Thomas Howerton Vanderford V
13. Viral transmission
Ivona Pandrea and Ann Chahroudi
14. Genetics of the host
Lutz Walter
15. The different modes of HIV/SIV control in monkeys and humans
Lisa Chakrabarti
16. Humans resembling natural hosts
Amalio Telenti and Paul McLaren
Epilogue: Implications for HIV infection
Aftab Ansari and Guido Silvestri
