Full Description
Cardiovascular disease is a major cause of mortality in the western world and about half of these deaths are caused by coronary artery disease. One of the most commonly used interventions to treat arterial blockages is to deploy an arterial stent to keep the vessel open. Traditionally, some cardiovascular stents have been associated with serious side-effects, such as thrombosis.
This book describes the fundamentals of cardiovascular stents, technologies to functionalize their surfaces and the market status of these important implants. The chapters provide specific focus on the production and evolution of cardiovascular stents, providing essential knowledge for researchers on advances in the field and knowledge of how cardiovascular stents are currently being "functionalized" in order to improve their biocompatibility and minimize negative outcomes in vivo.
Contents
Part One: Fundamentals of cardiovascular stents
1. Overview of cardiovascular stent designs
2. Fundamentals of bare metal stents
3. Development of drug eluting stents (DES)
4. Polymer-free drug-eluting stents
5. Fundamentals of bioresorbable stents
6. Bioabsorbable metallic stents
Part Two: Coatings and surface modification of cardiovascular stents
7. Physico-chemical stent surface modifications
8. Chemical vapor deposition of cardiac stents
9. Polymer coatings for biocompatibility and reduced nonspecific adsorption
10. Coating stability for stents
11. Simple one-step covalent immobilisation of bioactive agents without use of chemicals on plasma-activated low thrombogenic stent coatings
Part three: Biofunctionalisation of cardiovascular stent surfaces
12. Chemistry of targeted immobilisation of biomediators
12. In vitro coating of cardiovascular stents with cells (EPCs)
13. Functionalized cardiovascular stents: Cardiovascular stents incorporated with stem cells
14. Nitric oxide donor delivery
15. Immobilization of peptides on cardiovascular stent
16. Immobilisation of antibodies on cardiovascular stents
