基本説明
毒物中毒の臨床に関する全ての側面を網羅した、半世紀以上に亘って医師に最も信頼されてきたレファレンス、４年ぶりの改訂版。
Goldfrank's Toxicologic Emergencies is known worldwide as the most comprehensive and authoritative reference available on the management of poisoned and overdosed patients. This trusted classic covers all toxic substances - including drugs, plants, household and industrial chemicals, and heavy metals. Previous ed.: 2006.
Full Description
The most trusted, rigorous, and up-to-date toxicology resource and educational companion available - now in full colorA Doody's Core Title ESSENTIAL PURCHASE for 2011!Goldfrank's Toxicologic Emergencies continues to be the source you can turn to first for any poisoning or overdose. The text provides clear information on every aspect of toxicologic emergencies, from pharmacology to clinical presentation to management.Fully referenced and featuring a consistent organization, Goldfrank's begins with an in-depth examination of general principles of medical toxicology. It then progresses to the biochemical principles and molecular basis of toxicology, and provides detailed insight into how xenobiotics affect vital signs, organs, and systems throughout the body. Next, a wide spectrum of clinically important exposures -- including drugs, plants, metals, household products, occupational and environmental xenobiotics are covered within logical categories for easy access to information. Finally, the book concludes with sections on principles of practicing clinical toxicology in today's challenging healthcare environment.Full-color design and uniformly drawn figures clarify key conceptsSpecial Considerations focus on decision-making in unique toxicologic circumstances, that influence clinical practice and have the potential to improve patient care Antidotes in Depth, following pertinent chapters, place each antidote in its proper context to ensure immediate availability of essential information relevant for clinical useMore clinically-relevant figures and quick-reference tables Online learning center, available at www.goldfrankstoxicology.com, includes case studies, and a database of multiple choice questions that allow you to create a custom test for review and study. Every chapter is thoroughly rewritten and new chapters are added to reflect the very latest thinking in the field
Contents
Table of Antidotes in DepthContributorsPrefaceAcknowledgments1. Historical Principles and Perspectives, Paul M. Wax2. Toxicologic Plagues and Disasters in History, Paul M. Wax3. Initial Evaluation of the Patient: Vital Signs and Toxic Syndromes, Lewis S. Nelson, Neal A. Lewin, Mary Ann Howland, Robert S. Hoffman, Lewis R. Goldfrank, and Neal F. Flomenbaum4. Principles of Managing the Acutely Poisoned or Overdosed Patient, Lewis S. Nelson, Neal A. Lewin, Mary Ann Howland, Robert S. Hoffman, Lewis R. Goldfrank, and Neal F. Flomenbaum5. Diagnostic Imaging, David T. Schwartz6. Laboratory Principles, Petrie M. Rainey7. Techniques Used to Prevent Gastrointestinal Absorption, Anne-Bolette J. Christophersen and Lotte C.G. HoegbergA1. Syrup of Ipecac, Mary Ann HowlandA2. Activated Charcoal, Mary Ann HowlandA3. Whole-Bowel Irrigation and Other Intestinal Evacuants, Mary Ann Howland8. Pharmacokinetic and Toxicokinetic Principles, Mary Ann Howland9. Principles and Techniques Applied to Enhance Elimination, David S. Goldfarb10. Use of The Intensive Care Unit, Mark A. KirkSection 1: Biochemical and Molecular Basis11. Chemical Principles, Stephen J. Traub and Lewis S. Nelson12. Biochemical and Metabolic Principles, Kurt C. Kleinschmidt and Kathleen A. Delaney13. Neurotraansmitters and Neuromodulators, Steven C. Curry, Kirk C. Mills, Anne-Michalle Ruha, and Ayrn D. O'Connor14. Withdrawal Principles, Richard J. HamiltonSection 2: Pathophysiologic Basis: Organ Systems15. Thermoregulatory Principles, Susi U. Vassallo and Kathleen A. Delaney16. Fluid, Electrolyte, and Acid-Based Principles, Alan N. Charney and Robert S. Hoffman17. Psychiatric Principles, Kishor Malavade and Mark R. Serper18. Neurologic Principles, Rama B. Rao19. Ophthalmic Principles, Adhi Sharma20. Otolaryngologic Principles, William K. Chiang21. Respiratory Principles, Andrew Stolbach and Robert S. Hoffman22. Electrophysiologic and Electrocardiographic Principles, Cathleen Clancy23. Hemodynamic Principles, Robert A. Hessler24. Hematologic Principles, Marco L.A. Sivilotti25. Gastrointestinal Principles, Richard J. Church and Kavita M. Babu26. Hepatic Principles, Kathleen A. Delaney27. Renal Principles, Donald A. Feinfeld and Nikolas B. Harbord28. Genitourinary Principles, Jason Chu29. Dermatologic Principles, Neal A. Lewin and Lewis S. NelsonSection 3: Special Populations30. Reproductive and Perinatal Principles, Jeffrey S. Fine31. Pediatric Principles, Jeffrey S. Fine32. Geriatric Principles, Judith C. Ahronheim and Mary Ann Howland33. Postmortem Toxicology, Rama B. Rao and Mark FlomenbaumSC1. Organ Procurement from Poisoned Patients, Rama B. RaoSection 1: Case StudiesA. Analgesics and Antiinflammatory Medications34. Acetaminophen, Robert G. HendricksonA4. N-Acetylcysteine, Mary Ann Howland and Robert G. Hendrickson35. Salicylates, Neal E. FlomenbaumA5. Sodium Bicarbonate, Paul M. Wax36. Nonsteroidal Antiinflammatory Drugs, William J. Holubek37. Colchicine, Podophyllin, and the Vinca Alkoloids, Joshua G. SchierSC2. Intrathecal Administration of Xenobiotics, Rama B. Rao38. Opioids, Lewis S. Nelson and Dean OlsenA6. Opioid Antagonists, Mary Ann Howland and Lewis NelsonB. Foods, Dietary and Nutritional Agents39. Dieting Agents and Regimens, Jeanna M. Marraffa40. Iron, Jeanmarie PerroneA7. Deferoxamine, Mary Ann Howland41. Vitamins, Beth Y. Ginsburg42. Essential Oils, S. Eliza Halcomb43. Herbal Preparations, Oliver L. Hung44. Athletic Performance Enhancers, Susi U. Vassallo45. Food Poisoning, Michael G. Tunik46. Botulism, Howard L. GeyerA8. Botulinum Antitoxin, Lewis R. Goldfarb and Howard L. GeyerC. Pharmaceuticals47. Anticonvulsants, Suzanne DoyonA9. L-Carnitine, Mary Ann Howland48. Antidiabetics and Hypoglycemics, George M. BosseA10. Dextrose, Larissa I. Velez and Kathleen A. DelaneyA11. Octreotide, Mary Ann Howland49. Thyroid and Antithyroid Medications, Nicole C. Bouchard50. Antihistamines and Decongestants, Anthony J. Tomassoni and Richard S. WeismanA12. Physostigmine Salicylate, Mary Ann Howland51. Antimigraine Medications, Jason Chu52. Antineoplastics Overview, Richard Y. Wang53. Antineoplastics: Methotrexate, Richard Y. WangA13. Leucovorin (Folinic Acid) and Folic Acid, Mary Ann HowlandA14. Glucarpidase, (Carboxypeptidas G2), Silas W. SmithSC3. Extravasation of Xenobotics, Richard Y. Wang54. Miscellaneous Antineoplastics, Richard Y. Wang55. Pharmaceutical Additives, Sean P. Nordt and Lisa E. ViveroD. Antimicrobials56. Antibacterials, Antifungals, and Antivirals, Christine M. Stork57. Antituberculous Medications, Christina H. Hernon and Edward W. Boyer58. Antimalarials, J. Dave BarryE. Cardiopulmonary Medications59. Anticoagulants, Mark SuA16. Vitamin K, Mary Ann HowlandA17. Protamine, Mary Ann Howland60. Calcium Channel Blockers, Francis DeRoosA18. Insulin-Eyglycemia Therapy, William Kerns II61. B-Adrenergic Antagonists, Jeffrey R. BrubacherA19. Glucagon, Mary Ann Howland62. Other Antihypertensives, Francis DeRoos63. Antidysrhythmics, Lewis S. Nelson and Neal A. Lewin64. Cardioactive Steroids, Jason B. HackA20. Digoxin-Specific Antibody Fragments, Mary Ann Howland65. Methylxanthines and Selective B2 Adrenergic Agonists, Robert J. HoffmanF. Anesthetics and Related Medications66. Local Anesthetics, David R. Schwartz and Brian KaufmanA21. Intravenous Fat Emulsions, Todd Bania67. Inhalational Anesthetics, Brian Kaufman and Martin Griffel68. Neuromuscular Blockers, Kenneth M. SutinA22. Dantrolene Sodium, Kenneth M. SutinG. Psychotropic Medications69. Antipsychotics, David Juurlink70. Lithium, Howard A. Greller71. Monoamine Oxidase Inhibitors, Alex F. Manini72. Serotonin Reuptake Inhibitors and Atypical Antidepressants, Christine M. Stork73. Cyclic Antidepressants, Erica L. Liebelt74. Sedative-Hynotics, David C. Lee and Kathy FergusonA23. Flumazenil, Mary Ann HowlandH. Substances of Abuse75. Amphetamines, William K. Chiang76. Cocaine, Jane M. Prosser and Robert S. HoffmanSC4. Internal Concealment of Xenobiotics, Jane M. ProsserA24. Benzodiazepines, Robert S. Hoffman, Lewis S. Nelson, and Mary Ann Howland77. Ethanol, Luke YipA25. Thiamine Hydrochloride, Robert S. Hoffman78. Ethanol Withdrawal, Jeffrey Gold and Lewis S. Nelson79. Disulfiram and Disulfiram-Like Reactions, Edwin K. Kuffner80. Y-Hydroxybutyric Acid, Brenna M. Farmer81. Inhalants, Heather Long82. Hallucinogens, Kavita M. Babu83. Cannabinoids, Michael A. McGuigan84. Nicotine, Sari Soghoian85. Phencyclidine and Ketamine, Ruben Olmedo86. Aluminum, Brenna M. FarmerI. Metals87. Antimony, Asim F. Tarabar88. Arsenic, Stephen W. Munday and Marsha FordA26. Dimercaprol (British Anti-Lewisite or Bal), Mary Ann Howland89. Bismuth, Rama B. Rao90. Cadmium, Stephen J. Traub and Robert s. Hoffman91. Chromium, Steven B. Bird92. Cobalt, Gar Ming Chan93. Copper, Lewis S. Nelson94. Lead, Fred M. HenretigA27. Succimer (2,3-Dimercaptosuccinic Acid), Mary Ann HowlandA28. Edetate Calcium Disodium (CaNa2EDTA), Mary Ann Howland95. Manganese, Sari Soghoian96. Mercury, Young-Jin Sue97. Nickel, John Curtis and David A. Haggerty98. Selenium, Diane P. Calello99. Silver, Melisa W. Lai Becker and Michele Burns Ewald100. Thallium, Maria Mercurio and Robert S. HoffmanA29. Prussian Blue, Robert S. Hoffman101. Zinc, Nima MajlesiJ. Household Products102. Antiseptics, Disinfectants, and Sterilants, Paul M. Wax103. Camphor and Moth Repellents, Edwin K. Kuffner104. Caustics, Jessica A. Fulton105. Hydrofluoric Acid and Fluorides, Mark SuA30. Calcium, Mary Ann Howland106. Hydrocarbons, David D. Gummin107. Toxic Alcohols, Sage W. WienerSC5. Diethylene Glycol, Joshua G. SchierA31. Fomepizole, Mary Ann HowlandA32. Ethanol, Mary Ann HowlandK. Pesticides108. Pesticides: An Overview with a Focus on Principles and Rodenticides, Neal F. Flomenbaum109. Barium, Andrew Dawson110. Sodium Monofluoroacetate and Fluroacetamide, Fermin Barrueeto Jr.111. Phosphorus, Michael Beuhler112. Strychnine, Yiu-Cheung Chan113. Insecticides: Organic Phosphorus Compounds and Carbamates, Michael Eddleston and Richard F. ClarkA33. Pralidoxmine, Mary Ann HowlandA34. Atropine, Mary Ann Howland114. Insecticides: Organic Chlorines, Pyrethrins/Pyrethroids, and Insect Repellents, Michael G. Holland115. Herbicides, Darren M. Roberts116. Methyl Bromide and Other Fumigants, Keith K. BurkhartL. Natural Toxins and Envenomations117. Mushrooms, Lewis R. Goldfrank118. Plants, Mary Palmer and Joseph M. Betz119. Arthropods, In-Hei HahnA35. Antivenom (Scorpion and Spider), Richard F. Clark120. Marine Envenomations, D. Eric Brush121. Snakes and Other Reptiles, Bradley D. Riley, Anthony F. Pizon, and Anne-Michelle RuhaA36. Antivenom (Crotaline and Elapid), Anthony F. Pizon, Bradley D. Riley, and Anne-Michelle RuhaM. Occupational and Environmental Toxins122. Industrial Poisoning: Information and Control, Peter H. Wald123. Nanotoxicology, Silas W. Smith124. Simple Asphyxiants and Pulmonary Irritants, Lewis Nelson and Oladapo Obujebe125. Carbon Monoxide, Christian TomaszewskiA37. Hyperbaric Oxygen, Stephen R. Thom126. Cyanide Andhydrogen Sulfide, Christopher P. Hostege, Gary E. Isom, and Mark A. KirkA38. Sodium and Amyl Nitrites, Mary Ann HowlandA39. Sodium Thiosulfate, Mary Ann HowlandA40. Hydroxocobalamin, Mary Ann Howland127. Methemoglobin Inducers, Dennis P. PriceA41. Methylene Blue, Mary Ann Howland128. Smoke Inhalation, Nathan Charlton and Mark A. KirkN. Disaster Preparedness129. Risk Assessment and Risk Communications, Charles McKay, Jr.130. Hazmat Incident Response, Bradley Kaufman131. Chemical Weapons, Jeffrey R. Suchard132. Biological Weapons, Jeffrey R. Suchard133. Radiation, Joseph RellaA42. Potassium Iodide, Joseph RellaA43. Pentetic Acid (Dtpa) or Pentetate (Zinc or Calcium) Trisodium, Joseph RellaSection 2: Poison Centers and Epidemiology134. Poison Prevention and Education, Lauren Schwartz135. Poison Centers and Poison Epidemiology, Robert S. Hoffman136. International Perspectives on Toxicology, Michael Eddleston137. Principles of Epidemiology and Research Design, Kevin C. Osterhoudt138. Adverse Drug Events and Postmarketing Surveillance, Louis R., Cantilena139. Medication Safety and Adverse Drug Events, Brenna M. Farmer140. Risk Management and Legal Principles, Barbara M. Kirrane and Dainius A. DrukteinisIndexNER(01): WOW
