有機化学研究法：生化学、分子生物学、医学、薬学（テキスト） Organic Chemical Methods : in Biochemistry, Molecular Biology, Medicine, and Pharmacy

著者名：Krois, Daniel

Springer（2026/08/02発売）

• 言語：ENG
• ISBN：9783662735725
• eISBN：9783662735732

Description

This book explains synthetic and analytical methods of organic chemistry that are used in applications and research in biochemistry, molecular biology, medicinal chemistry, and pharmaceutical chemistry. It is intended as a textbook for master’s studies in chemistry as well as in biological and medicinal‑chemical disciplines. Owing to the extensive literature references, it is also suitable as a monograph for practitioners in research laboratories.

A basic understanding of organic chemistry is assumed, but essential aspects are reviewed in Chapters 1 and 2. Part 1 of the book covers general methods for the three main groups of biopolymers: peptides and proteins, carbohydrates and glycoconjugates, and nucleic acids. Chapter 7 introduces conjugate formation for labeling biomolecules. Part 2, on the other hand, highlights selected topics based on specific recent publications. This allows readers to follow the application of the methodology developed in Part 1 within a biological context. The teaching objective of this book is to illustrate method development for biological questions to chemistry students and thereby encourage further advancement. Students and researchers from biological and medical fields are intended to gain a better understanding of both the possibilities and the underlying principles of the methodologies. This is meant to foster interdisciplinary understanding. 

Table of Contents

Brief review of fundamental concepts of general and organic chemistry.- Chemical properties of biomolecules.- A summary.- Methods for the synthesis and analysis of peptides and proteins.- Oligosaccharides (carbohydrates).- Glycoconjugates, glycoproteins.- Oligonucleotides and nucleic acids.- Preparation of conjugates.- Ligation methods for the chemical synthesis and semisynthesis of proteins.- Synthesis of lipopeptides and protein conjugates related to the function of the N‑Ras protein.- Development of peptide‑based synthetic vaccines.- Applications of modified oligonucleotides.- Methods for modifying proteins – introduction of non‑natural amino acids.- Optimization of structure–activity relationships (SAR): development of inhibitors and agonists.- Fluorescent compounds.- Solutions.