Description
Nutritional Epigenomics, Second Edition, a volume in the Translational Epigenetics, offers a comprehensive overview of nutritional epigenomics as a mode of study, along with nutrition's role in the epigenomic regulation of disease, health, and developmental processes. Here, an expert team of international contributors introduces readers to nutritional epigenomic regulators of gene expression, our diet's role in epigenomic regulation of disease and disease inheritance, caloric restriction and exercise as they relate to recent epigenomic findings, and the influence of nutritional epigenomics over circadian rhythms, aging and longevity, and fetal health and development, among other processes. Disease specific chapters address metabolic disease (obesity and diabetes), cancer, and neurodegeneration, among other disorders. Diet-gut microbiome interactions in the epigenomic regulation of disease are also discussed, as is the role of micronutrients and milk miRNAs in epigenetic regulation. Finally, chapter authors examine ongoing discussions of race and ethnicity in the social-epigenomic regulation of health and disease.This new edition has been fully updated to reflect current research in the field. All-new and revised chapters consider the social and physical environments associated with DNA methylation, the relationship between nutritional epigenomics and inflammation, chromatin modifications and non-coding RNAs, as well as the epigenetic influence of food bioactives in metabolic disease and cancer, empowering researchers to employ nutritional epigenomics approaches in new, field-driving studies and applications.- Empowers researchers and clinicians to employ nutritional epigenomics approaches in their own research and practice- Offers a full grounding in epigenetic reprogramming and nutritional intervention in the treatment and prevention of disease, as informed by population-based studies- Concludes with clinical recommendations and practical applications related to nutrition and lifestyle choices- Fully considers recent advances in the field, including new research into chromatin modifications, non-coding RNAs, and fiber regulation of the microbiome and human health- Features chapter contributions from international leaders in the field
Table of Contents
SECTION I Introduction1. Introduction to nutritional epigenomicsSECTION II Epigenetic regulators2. DNA methylation and chromatin modifications3. Small non-coding RNAs as epigenetic regulatorsSECTION III Epigenomic regulation of disease4. The impact of race and ethnicity in the social epigenomic regulation of disease5. The epigenomic impact of methylation in metabolic dysfunction and cancer6. The role for DNA/RNA methylation on neurocognitive dysfunctions7. Histone acylation in the epigenomic regulation of insulin action and metabolic disease8. Cancer and non-coding RNAs 8. Race in the social-epigenomic regulation of pre- and perinatal development9. Social and Physical environments in the control of DNA methylation and inflammation during early development10. Maternal nutrition, epigenetic programming and metabolic syndrome 11. Epigenetic inheritance of metabolic signals12. The paternal diet regulates the offspring epigenome and healthSECTION V Nutritional epigenomics and the circadian clock13. The interplay between diet, epigenetics and the circadian clock14. Epigenetic regulation of the fetal circadian clock: implications for nutritional programming of circadian and metabolic function15. The role for the microbiome in the regulation of the circadian clock and metabolismSECTION VI Caloric restriction and exercise in the epigenomic regulation of aging and disease16. Epigenomic reprogramming of caloric restriction on aging17. Dietary restriction in the epigenomic regulation of cardiovascular diseases18. Epigenomic adaptations of exercise in the control of metabolic disease and cancerSECTION VII Macro- and micronutrients as epigenomic regulators of health and disease19. B-vitamins and one-carbon metabolism: impacts on the epigenome during development20. Food bioactives in the epigenomic regulation of metabolic disease 21. Phytochemicals as dietary regulators of the cancer epigenome22. Regulation of non-coding RNAs by phytochemicals for cancer therapy23. Short chain fatty acids as epigenetic and metabolic regulators of neurocognitive health and disease
