セルディンの腎臓学（第６版・全２巻） Seldin and Giebisch's The Kidney : Physiology and Pathophysiology（6）

著者名：Alpern, Robert J. (EDT)/Caplan, Michael J. (EDT)/Moe, Orson W. (EDT)/Quaggin, Susan E. (EDT)

Academic Press（2026/05/08発売）

• 言語：ENG
• ISBN：9780128153895
• eISBN：9780128153901

Description

Seldin and Giebisch's The Kidney: Physiology and Pathophysiology, Sixth Edition provides a common language for nephrology researchers, fellows, and practicing nephrologists to discuss normal and abnormal renal physiology and the development and diagnosis of a wide range of renal diseases. Guided by a team of four distinguished authorities in nephrology, experts from all areas of renal research and practice take readers from the structure and function of the normal kidney, to the specific cellular and molecular mechanisms underlying disease development, and into the management of renal disease through physiologic regulation. This classic nephrology reference for nearly 30 years combines basic and clinical sciences that provides authoritative, concise, and readily accessible information. Academic, medical, and pharma researchers save valuable time by quickly accessing the very latest details on renal physiology and pathophysiology as opposed to searching through thousands of journal articles.- Presents the most comprehensive, translational source for all aspects of normal renal physiology and pathophysiology of kidney diseases in one reference work- Offers clear translational presentations by the top basic and clinical researchers in each specific renal disease, including fluid and electrolyte disorder, genetic disorders, glomerular diseases, diabetic nephropathy, preeclampsia, dialysis and transplantation

Table of Contents

Volume 1I: Epithelial and Nonepithelial Transport and Regulation1. Epithelial Cell Structure and Polarity2. Mechanisms of Ion Transport across Cell Membranes3. Renal Ion-Translocating ATPases4. Mechanisms of Water Transport Across Cell Membranes and Epithelia5. Cell Volume Control6. Solute Transport, Energy Consumption, and Production in the Kidney7. Electrophysiological Analysis of Transepithelial Transport8. Renal Ion Channels, Electrophysiology of Transport, and Channelopathies9. Microvascular Permeability and the Exchange of Water and Solutes Across Microvascular Walls10. External Balance of Electrolytes and Acids and Alkali11. Renal Cilia Structure, Function, and Physiology12. Intercellular Junctions13. Principles of Cell Signaling14. Scaffolding Proteins in Transport Regulation15. The Renin–Angiotensin System16. Neural Control of Renal Function17. Eicosanoids and Renal Function18. Extracellular Nucleotides and Renal Function19. Paracrine Regulation of Renal Function by DopamineII: Structural and Functional Organization of the Kidney20. Structural Organization of the Mammalian Kidney21. Biophysical Basis of Glomerular Filtration22. Glomerular Cell Biology23. Function of the Juxtaglomerular Apparatus: Control of Glomerular Hemodynamics and Renin Secretion24. Renal Cortical and Medullary Microcirculations: Structure and Function25. Molecular and Cellular Mechanisms of Kidney Development26. Molecular and Cellular Mechanisms of Glomerular Capillary Development27. Postnatal Renal Development28. Renal Hyperplasia and Hypertrophy29. Stem Cells and Generation of New Cells in the Adult KidneyIII: Fluid and Electrolyte Regulation and Dysregulation30. Epithelial Na+ Channels31. Anion Channels32. Physiology and Pathophysiology of the NaCl Co-Transporters in the Kidney33. Sodium and Chloride Transport: Proximal Nephron34. Sodium Chloride Transport in the Loop of Henle, Distal Convoluted Tubule, and Collecting Duct35. Mineralocorticoid Action in the Aldosterone Sensitive Distal Nephron36. Inherited Disorders of Renal Salt Homeostasis: Insights from Molecular Genetics Studies37. Natriuretic Hormones38. Pathophysiology of Sodium Retention and Wastage39. Physiology and Pathophysiology of Hypertension40. Physiology and Pathophysiology of Diuretic Action41. Aquaporin Water Channels in Mammalian Kidney42. Thirst and Vasopressin43. The Urine Concentrating Mechanism and Urea Transporters44. Hyponatremia45. Hypernatremic States46. Polyuria and Diabetes Insipidus47. The Molecular Biology of Renal K+ Channels48. Extrarenal Potassium Metabolism49. Regulation of K+ Excretion50. Physiopathology of Potassium DeficiencyVolume II51. Clinical Disorders of Hyperkalemia52. Control of Intracellular pH53. SLC4 Sodium-Driven Bicarbonate Transporters54. The SLC4 Anion Exchanger Gene Family55. Cellular Mechanisms of Renal Tubular Acidification56. Chemoreceptors, Breathing and pH57. Renal Ammonium Ion Production and Excretion58. Clinical Syndromes of Metabolic Alkalosis59. Clinical Syndromes of Metabolic Acidosis60. Respiratory Acid–Base Disorders61. Mechanisms and Disorders of Magnesium Metabolism62. Calcium Channels63. The Calcium-Sensing Receptor64. Renal Calcium Metabolism65. The Hormonal Regulation of Calcium Metabolism66. Disorders of Calcium Metabolism67. Pathogenesis and Treatment of Nephrolithiasis68. Proximal Tubular Handling of Phosphate69. Clinical Disturbances of Phosphate Homeostasis70. Glucose Reabsorption in The Kidney71. Kidney Transport of Amino Acids and Oligopeptides, and Aminoacidurias72. Organic Anion and Cation Transporters in Renal Elimination of Drugs73. Renal Filtration, Transport, and Metabolism of Albumin and AlbuminuriaIV: Pathophysiology of Renal Disease74. Physiologic Principles in the Clinical Evaluation of Electrolyte, Water, and Acid–Base Disorders75. Biomarkers for Assessment of Renal Function During Acute Kidney Injury76. Pathophysiology of Acute Kidney Injury77. Ischemic Renal Disease78.