Description
Retinoic Acids in Cancer Therapy: Mechanisms of Sensitivity, Resistance, and Methods of Delivery provides an overview of how All-Trans Retinoic Acid (ATRA) kills cancer cells and how some cells survive treatment. Focusing on the cellular pathways and compartments involved in ATRA-mediated inhibition of proliferation, this book also discusses how aggressive tumors develop escape routes conferring retinoic acid resistance.Across 15 chapters, it describes the molecular structure and biological properties of ATRA, explains mechanisms of resistance, and defines ATRA's efficacy in seven cancer types. It concludes with chapters on ATRA and cancer stem cell biology, strategies to improve treatment, future therapeutic perspectives, and delivery methods to reduce toxicity and enhance anticancer efficacy.Each chapter includes Learning Objectives and a "What We Learn" section, making the book highly accessible for undergraduate, graduate trainees, scientists, physicians, and biotech companies. Adding simple, attractive schemes and informative tables makes it ideal for all interested in the current status of Retinoic Acids in Cancer Therapy. This book serves as a valuable resource for health professionals, scientists, researchers, clinical practitioners, and all those seeking to broaden their knowledge and develop new drugs or therapeutic strategies to improve ATRA's efficacy in the treatment of resistant cancers.- Includes Learning Objectives and "What We Learn" sections in every chapter- Presents concise schematic figures illustrating apoptotic and autophagic pathways- Explains the interplay of apoptosis (intrinsic and extrinsic) and autophagy in ATRA-induced cell death- Discusses autophagy targeting to enhance ATRA effectiveness- Examines cancer stem cell fate modulation with ATRA- Highlights future directions and delivery strategies to minimize off-target effects
Table of Contents
1. Molecular structure and biological properties of all-trans retinoic acid2. Emerging frontiers in drug development of all-trans retinoic acid and its derivatives3. Cellular and molecular determinants of all trans retinoic acid sensitivity in different cancers4. Apoptosis, autophagy, and unfolded protein response and their impact on all-trans retinoic acid induced toxicity in cancer cells5. Mechanisms of resistance to all-trans retinoic acid and use of multi-target-directed ligand to fight against resistance6. Nanocarrier systems for targeted delivery of all-trans retinoic acid: design and mechanisms7. Advanced delivery systems for all-trans retinoic acid: challenges and opportunities in pharmacokinetics and bioavailability8. Mechanisms of sensitivity, resistance, and methods of delivery9. Efficiency of all-trans retinoic acid on gastric cancer10. All-trans retinoic acid and its role in glioblastoma therapy11. All-trans retinoic acid and vitamin A in neurodegeneration: from oncology to neuroprotection12. Efficiency of all-trans retinoic acid in liver cancer13. Efficiency of all-trans retinoic acid on colon cancer14. Retinoic acids in head and neck cancer therapy: mechanisms of sensitivity, resistance, and methods of delivery15. Role of artificial intelligence and machine learning in predicting all-trans retinoic acid treatment outcomes
