Description
The Itch Spectrum: The Neurological and Immunological Basis of Itch and Dermatological Disorders covers the latest research on the itch signalling pathway from the skin to the brain. With a multidisciplinary approach, this book will cover the mechanisms underlying the sensation of itch from the fields of neuroscience, immunology, genetics, and dermatology as they have intersected in the study of one somatosensory system. The purpose of this comprehensive reference is to summarize the revelatory discoveries in the field of itch and provide a comprehensive overview of what is known about this remarkable sensation and how various pathologies contribute to chronic pruritis.- Offers a comprehensive overview of the neurological underpinnings, immune and neuroimmune interactions, and more- Features an in-depth review of scientific literature from interdisciplinary fields- Provides clinical insights which corresponds with basic research
Table of Contents
Section 1: Preclinical Perspective1. Historical perspective of itch research2. Primary afferent neurons involved with itch3. Receptors of itch: GPCRs4. TRP channels for itch5. Ion channels for itch6. Neuroimmune interactions in itch7. Cytokine in itch induction and modulation8. Mast cells and itch9. Bacteria and Virus Induced itch10. Spinal pathways and projection neurons for itch11. Spinal Glia–Neuron interactions in chronic itch12. Central targets for itch13. Aversive and reward circuits in itch processing14. Descending modulation of itch15. Neural coding of itch versus pain16. Mechanical itch and alloknesis17. Mouse models for acute itch18. Mouse models of chronic itch19. Mucosal itch20. Drug induced itch21. Conservation of itch across speciesSection 2: Clinical Perspectives22. Epidemiology of itch23. Atopic dermatitis24. Psoriasis25. Prurigo nodularis26. Cholestatic and uremic itch27. Neuropathic itch28. Itch caused by connective tissue diseases29. fMRI and itch30. Recent advances for drug targets to treat itch
