Description
The Resistance of Cervical Cancer to Chemotherapy and its Reversal provides a holistic understanding of cervical cancer development, immune-evading mechanisms of HPV, immunotherapies available, methods to study cervical cancer and the development of newer drugs. Content shows the involvement of signaling pathways during chemoresistance in cervical cancer, the involvement of genes in drug resistance, and introduces long noncoding RNAs as novel biomarkers.In 10 chapters, this book first provides an introduction and history of cervical cancer; next, it discusses the influence of viruses on cervical cancer and finally, it describes therapies to overcome chemotherapy resistance in cervical cancer. This is the perfect reference to provide the fundamental base of knowledge needed for oncologists, pharmacologists, translational investigators, immunotherapists, scientists, and clinicians interested in building a comprehensive understanding of the field.- Focuses on the aspects of cervical cancer resistance towards therapies such as chemoresistance and radioresistance- Discusses the sensitizing agents that are being developed for the improvement of current therapies and better management of cervical cancer- Identifies the molecular mechanism of HPV integration and cervical cancer development
Table of Contents
- Role of Wnt/β‑catenin signaling pathway in cervical cancer: Strategies to overcome therapeutic resistance- Targeting epigenetic regulatory machinery to overcome cervical cancer chemoresistance- The role of immune checkpoint proteins PD1 and PD‑L1 during cancer resistance- Advancements in radiotherapy: transforming cervical cancer treatment- Pathogenesis of human papillomavirus induced carcinogenesis: insights on in vivo models and prophylactic strategies- Subcellular transport of epidermal growth factor receptor: diverse approaches in targeting epidermal growth factor receptor‑driven cervical carcinoma- Structural insights into Human papillomavirus E6 and E7 oncoproteins: implications for drug design and therapeutic targeting- Critical insights to understand the underlying mechanisms in cervical cancer metastasis- Advancements of cytology in cervical cancer- Insights on molecular mechanisms of chemoresistance in cervical cancer- Computational techniques to study the cervical cancer- Advances in nanotechnology‑based drug development and delivery for cervical cancer therapeutic strategies
