Description
Antimicrobial Therapeutics and Drug Discovery is a comprehensive resource that provides an overview of antimicrobial drug discovery. It covers a wide spectrum of pathogenic organisms causing human infections, exploring alternative therapeutic strategies beyond traditional small molecule drugs. The contents in the book are structured into four parts, each focusing on a different aspect of antimicrobial drug discovery. From exploring viral and host targets, understanding antibiotic resistance mechanisms, to the potential of nanomedicine and computational approaches, the book offers a comprehensive view of the field. Employing a multidisciplinary approach, chapters discuss the importance of drug discovery for fungi, Mycobacteria, Mycoplasma, and parasites, and offers insights into innovative biomedical approaches and combination therapies. By bridging the gap between experimental research and practical application, Antimicrobial Therapeutics and Drug Discovery is a key reference for pharmacologists and pharmaceutical scientists working in academic and corporate research. Medicinal chemists and microbiologists will also benefit from the multidisciplinary coverage of the book.- Provides a comprehensive overview of antimicrobial drug discovery- Discusses ethical imperatives in combating antimicrobial resistance- Offers insights into drug discovery for overlooked pathogens- Explores alternative therapeutic strategies for combating antibiotic resistance- Bridges the gap between experimental research and practical application
Table of Contents
Part I: Antiviral Drug Discovery1. Exploring Viral and Host Targets for Antiviral Drug Discovery2. COVID-19 Challenges and its Therapeutics3. From Lab to Clinic: The Evolution of Reverse Transcriptase Inhibitors in HIV Treatment4. Targeting Hepatitis C Virus Polymerase: Non-Nucleoside Inhibitors (NNIs) and Drug Resistance5. Challenges, Progress, and Prospects of Drug Discovery to Treat Chronic Hepatitis B (CHB) Infection6. Discovery and Development of Antiviral Therapies for Influenza Virus Infections7. Medicinal Chemistry Strategies for the Discovery and Development of Anti-Herpesvirus Drugs8. Opportunities and Challenges in Targeted Protein Degradation for Antiviral Drug DiscoveryPart II: Antibacterial Drug Discovery9. Molecular Mechanisms of Antibiotic Resistance10. Overview of the Antibiotics Approved in the Last Two Decades: Retrospect and Prospect11. Antibiotic Resistance Breakers: Current Approaches and Future Directions12. Innovative Approaches in Developing Antimicrobial Peptides for Drug-Resistant Bacterial Infections13. The Potential of Antibody-Antibiotic Conjugates in Combatting Bacterial Diseases14. Phage Therapy: Current Advancements and Future Prospects in Combating Antimicrobial ResistancePart III: Drug Discovery for Miscellaneous Pathogens15. Antifungal Drug Resistance: Current Mechanisms and Future Directions16. Challenges, Unmet Clinical Needs, and Novel Approaches in the Discovery of Antifungal Drugs17. Drug Discovery against Mycobacteria: The Success and Challenges18. Future of Drug Development for the Treatment of Mycoplasma Infections19. Antimalarial Drug Discovery: From Novel Molecules to Clinical DevelopmentPart IV: Next-Generation Antimicrobial Strategies20. Computational Approaches in Antimicrobial Drug Discovery21. Multi-Omics Approaches for Antimicrobial Drug Discovery22. Nanomedicine as a Next-Generation Antimicrobial Therapy: New Frontiers in Fighting Microbial Infections23. Drug Repurposing: Innovative Antimicrobial Strategies to Combat Resistance24. Drug Combinations: A Strategy to Extend the Life of Antimicrobials25. Ethical Imperatives in Combating Antimicrobial Resistance: A Global Perspective
