Description
A comprehensive, up-to-date discussion of what enzymes are, how they work, and how they catalyse enzymatic reactions
Enzymes are giant macromolecules which catalyse all the biochemical reactions in living cells. Their three-dimensional structures are highly complex, yet they are formed by spontaneous folding of a linear polypeptide chain. Their catalytic properties are even more impressive than synthetic catalysts which operate under more extreme conditions. Enzyme-catalysed reactions proceed very high enantioselectivity and enantiospecificity at rates which approach “catalytic perfection.” Living cells carry out a huge repertoire of enzyme-catalysed chemical reactions, some of which have little or no precedent in organic chemistry.
The popular textbook Introduction to Enzyme and Coenzyme Chemistry has been thoroughly updated with information on the most recent advances in our understanding of enzyme action. This newly revised fourth edition includes:
- New case studies
- A new section on oxygen activation by enzymes
- Expanded sections on membrane proteins, enzyme purification, enzymatic phosphoryl transfer reactions, fatty acid biosynthesis and polyketide biosynthesis
- Additional examples from recent literature used to illustrate key points
- Additional problems and solutions outlined and updated Further Reading sections at the end of each chapter
- Over 40 full-colour figures of the active sites of enzymes that illustrate the interplay between enzyme structure and function
Introduction to Enzyme and Coenzyme Chemistry provides a concise but comprehensive account from the perspective of organic chemistry that explains what enzymes are, how they work, and how they catalyse many of the major classes of enzymatic reactions. It will prove invaluable to undergraduate and postgraduate students of organic, bio-organic and medicinal chemistry, chemical biology, biochemistry and biotechnology.
Table of Contents
Biography vii
Preface to 4th Edition ix
Representation of Protein Three-Dimensional Structures xi
Chapter 1 From Jack Beans to Designer Genes 1
Chapter 2 All Enzymes Are Proteins 9
Chapter 3 Enzymes Are Wonderful Catalysts 29
Chapter 4 Methods for Studying Enzymatic Reactions 55
Chapter 5 Hydrolytic and Group Transfer Enzymes 85
Chapter 6 Enzymatic Redox Chemistry 129
Chapter 7 Enzymatic Carbon–Carbon Bond Formation 169
Chapter 8 Enzymatic Addition/Elimination Reactions 209
Chapter 9 Enzymatic Transformations of Amino Acids 227
Chapter 10 Isomerases 245
Chapter 11 Radicals in Enzyme Catalysis 261
Chapter 12 Non-Enzymatic Biological Catalysis 283
Appendix 1: Cahn-Ingold-Prelog Rule for Stereochemical Nomenclature 303
Appendix 2: Amino Acid Abbreviations 305
Appendix 3: A Simple Demonstration of Enzyme Catalysis 307
Appendix 4: Answers to Problems 309
Index 319
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