ATP : From Neurotransmission to Cancer Therapy

著者名：Sluyter PhD, Ronald (EDT)/Cederholm PhD, Jennie M.E. (EDT)/Stokes PhD, Leanne (EDT)/Ulrich PhD, Henning (EDT)/Vlajkovic PhD, Srdjan (EDT)/Tang PhD, Yong (EDT)

Academic Press（2026/02/21発売）

• 言語：ENG
• ISBN：9780443302503
• eISBN：9780443302510

Description

ATP: From Neurotransmission to Cancer Therapy delivers a comprehensive discussion of extracellular ATP biology and its communication role in both homeostasis and pathologic states. It explores the function of ATP across the nervous, sensory, musculoskeletal, cutaneous cardiovascular, pulmonary, gastrointestinal, urinary, reproductive, exocrine, haematopoietic and immune systems. The book considers ATP in the context of various disease states, including cardiovascular, respiratory, psychiatric, inflammatory and neurodegenerative disorders, as well as pain and sensory disorders, infectious diseases, and cancer. ATP in humans is explored alongside other species, including rodents, fish, and plants. This is the latest volume in the "Molecular Mediators in Health and Disease" series. With contributions from specialists across pharmacology, physiology, biophysics, biochemistry, immunology, anatomy, molecular biology, therapeutics, and other critical fields, this volume provides a broad and detailed overview of ATP which will be helpful to researchers working in these areas and beyond.- Considers extracellular ATP across various organs including the lung, heart, liver and kidneys- Investigates ATP across a range of conditions such as age-related disorders, cardiovascular disease, respiratory disease and psychiatric disorders- Explores the biochemistry and molecular biology of extracellular ATP signalling- Looks at the history of ATP and its discovery in addition to future perspectives

Table of Contents

Part I - Introduction to extracellular ATP1. History of ATP and purinergic signalling2. Extracellular ATP in normal biologyPart II – Molecular biology of extracellular ATP signalling3. Extracellular ATP4. P2X receptors5. P2Y receptors6. Regulation of extracellular ATP by ectonucleotidasesPart III – Extracellular ATP in organ function7. Extracellular ATP and the oral cavity8. Extracellular ATP and blood vessels9. Extracellular ATP and the heart and carotid body10. Extracellular ATP and the lung11. Extracellular ATP and metabolism12. Extracellular ATP and the gastrointestinal tract13. Extracellular ATP and the liver14. Extracellular ATP and the pancreas15. Extracellular ATP and the kidneys16. Extracellular ATP and the bladder17. Extracellular ATP and the central nervous system18. Extracellular ATP and the peripheral nervous system19. Extracellular ATP and the eye20. Extracellular ATP and the ear21. Extracellular ATP and the reproductive organs22. Extracellular ATP and the skin23. Extracellular ATP and the bone24. Extracellular ATP and skeletal muscle25. Extracellular ATP and haematopoietic stem and progenitor cells26. Extracellular ATP and platelets27. Extracellular ATP and red blood cells28. Extracellular ATP and innate immune cells29. Extracellular ATP and adaptive immune cellsPart IV - Pharmacology of extracellular ATP signalling30. Extracellular ATP and P2X receptors)31. Extracellular ATP and P2Y receptorsPart V - Extracellular ATP in non-mammalian biology32. Extracellular ATP in fish33. Extracellular ATP in primitive species34. Extracellular ATP in plantsPart VI - Extracellular ATP in Disease35. Extracellular ATP in aged-related disorders36. Extracellular ATP in cardiovascular disorders37. Extracellular ATP in respiratory disorders38. Extracellular ATP in gastrointestinal disorders40. 39. Extracellular ATP in brain diseases41. Extracellular ATP in neurodegenerative disorders42. Extracellular ATP in psychiatric disorders43. Extracellular ATP in pain44. Extracellular ATP in other sensory disorders45. Extracellular ATP in infectious disease46. Extracellular ATP in inflammatory disorders47. Extracellular ATP in cancer48. Extracellular ATP and future directions