Description
Microglial Aging: Basic, Translational, and Clinical Advances explores groundbreaking research on microglial function in the context of aging. This comprehensive resource delves into the physiological roles of microglia, the effects of aging on their structure and activity, and their significance in age-related neurodegenerative diseases. With insights from basic, translational, and clinical studies, it provides a thorough understanding of microglial health and its impact on aging. The book discusses how lifestyle choices can enhance microglial functions and prevent neurodegenerative diseases. It covers both pharmacological and non-pharmacological approaches, such as the ketogenic diet, cannabinoids, psychedelics, and non-invasive vagal nerve stimulation.This text is invaluable for researchers and clinicians focused on improving the quality of life for an aging population.- Covers basic, translational, and clinical research advances in microglial aging- Reviews the most up-to-date research findings on microglial aging and their implication in age-related neurodegenerative diseases- Includes current knowledge on the effects of lifestyle on microglial aging and on promising strategies, both pharmacological and non-pharmacological, for rejuvenating microglia
Table of Contents
Section 1. Introduction to microglial aging and its involvement in neurodegenerative diseases1. The microglial aging process at cellular and molecular levels across its different layers of complexity2. Involvement of microglial aging in neurodegenerative diseases: a focus on Alzheimer's disease3. Involvement of microglial aging in neurodegenerative diseases: a focus on Parkinson's disease4. Involvement of microglial aging in neurodegenerative diseases: a focus on multiple sclerosis5. Involvement of microglial aging in neurodegenerative diseases: a focus on amyotrophic lateral sclerosis6. Involvement of microglial aging in neurodegenerative diseases: a focus on vascular cognitive impairment and dementiaSection 2. Outcomes of the lifestyle on microglial aging and neurodegenerative diseases along the aging trajectory7. Diet and the gut-brain axis8. Sleep disturbances9. Psychological stress10. Bacterial and viral infections11. Physical activity12. Substance useSection 3. Emerging treatment strategies to rejuvenate microglia in aging and neurodegenerative diseases13. Ketogenic diets and supplements14. Senolytic drugs15. Cannabinoids16. Psychedelics17. Plasmalogens18. Multi-modal lifestyle interventions
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