Description
Antibiotic Resistance and Nanotherapy is a comprehensive guide that explores an interdisciplinary approach to address the pressing issue of antibiotic resistance and explores the possibility of nanotherapy as a cutting-edge strategy to treat illnesses that are resistant to antibiotics, employing nanoparticles to target and kill bacteria selectively without damaging healthy cells. It details the underlying mechanisms of drug resistance in intracellular and extracellular pathogens and explores the latest advancements in nanotechnology, including the development of innovative nanomaterials and delivery systems that can be utilized to combat antibiotic-resistant infections. This book also discusses the ethical and practical challenges associated with implementing nanotherapy for bacterial resistance. Featuring contributions from experts in the field, this book is an essential resource for researchers, medical professionals, and policymakers seeking to understand and tackle the immediate threat posed by antibiotic resistance.- Examines the current state of antimicrobial resistance, its impact on global health, and the rise of drug-resistant "superbugs"- Demonstrates how nanotherapeutics using diverse nanoparticles can be used to address antibiotic resistance- Provides in-depth discussions of the mechanisms underlying antibiotic resistance, the prospect of antibiotic-resistant infection treatments based on nanotechnology, and the most recent developments in nanotechnology-based diagnostics
Table of Contents
1. Introduction to planktonic and biofilm-mediated antimicrobialresistance and role of nanotechnology in overcoming biofilm-mediatedantibiotic resistance2. Key determinants of antimicrobial resistance: exploring the influence ofantibiotic pollution on the emergence of multidrug-resistant microbes3. Drug resistance mechanism in intracellular pathogens and modulation4. Metal-based nanomedicine against intracellular pathogens5. Lipid-based nanomedicine against intracellular pathogens6. Metal-based nanomedicine against extracellular pathogens7. Polymer-based nanomedicine against extracellular pathogens8. Lipid-based nanomedicine against extracellular pathogens9. Interaction between infected host cells and nanodelivery systems10. Innovative strategies utilizing nanoparticles to disrupt c-di-GMP andquorum-sensing signaling pathways to combat antibiotic resistanceinduced by biofilms11. CRISPR-Cas systems for antibiotic resistance12. Synergistic effects of natural compounds and repurposed drugs innanotherapy: a strategy to combat biofilm-associated infections13. Safety, ethical, regulatory issues, and challenges of nanotherapy forantimicrobial resistance
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